稳定期COPD患者营养状况与血清脂联素、肺功能、CAT评分的关系

发布时间：2018-04-20 19:27

本文选题：COPD + 营养不良　；参考：《安徽医科大学学报》2014年07期

【摘要】：目的探讨稳定期慢性阻塞性肺疾病(COPD)患者血清脂联素水平、肺功能、慢性阻塞性肺病评估测试(CAT)得分与营养状况的关系。方法收集稳定期COPD患者77例,利用CAT评分评估患者临床症状严重程度,40例同期的体检健康者作为正常对照组,按简易营养评价精法(MNASF)将其分为营养不良组(49例)和非营养不良组(28例),各组均行空腹血清脂联素浓度及肺功能检测。结果正常对照组脂联素浓度最高,非营养不良组血清脂联素浓度低于营养不良组,但各组间差异无统计学意义(P0.05);营养不良组患者的第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC(用力最大肺活量百分比)、FEV1%占预计值百分比(FEV1%pred)较非营养不良组均有显著下降,差异具有统计学意义(P0.01);营养不良组CAT评估所得分数较非营养不良组明显下降,差异有统计学意义(P0.01);MNA-SF得分与FEV1、FVC、FEV1/FVC以及FEV1%pred呈显著正相关,与CAT得分呈显著负相关,与脂联素浓度无明显相关性。结论稳定期COPD患者的营养状况与FEV1/FVC、FEV1、FVC、FEV1%pred及其临床症状严重程度存在显著相关性,因而提高患者的营养状况有助于改善患者的预后和生存质量;而脂联素是否参与了COPD稳定期患者的营养不良的发生,此次研究结果尚未得到证实。
[Abstract]:Objective to investigate the relationship between serum adiponectin level, pulmonary function, CAT score and nutritional status in patients with stable chronic obstructive pulmonary disease (COPD). Methods Seventy-seven patients with stable COPD were collected and 40 healthy controls were used to evaluate the severity of clinical symptoms by CAT score. It was divided into two groups according to the simple method of nutrition evaluation: 49 cases of malnutrition group (n = 49) and 28 cases of non-malnutrition group (n = 28). Fasting serum adiponectin concentration and pulmonary function were measured in all groups. Results the concentration of adiponectin in normal control group was the highest, and the serum adiponectin concentration in non-malnutrition group was lower than that in malnutrition group. But there was no significant difference among the groups (P 0.05), the forced expiratory volume in the first second and FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / FVCin the malnutrition group were significantly lower than those in the non-malnutrition group. The score of CAT evaluation in malnutrition group was significantly lower than that in non-malnutrition group, and the difference was statistically significant. There was a significant positive correlation between the score of MNA-SF and FEV1 / FVC / FEV1 / FVC and FEV1%pred, and a significant negative correlation with CAT score. There was no significant correlation between adiponectin concentration and adiponectin concentration. Conclusion there is a significant correlation between the nutritional status of patients with stable COPD and FEV1 / FV1 / FEV1 / FEV1pred and the severity of their clinical symptoms. Therefore, improving the nutritional status of the patients is helpful to improve the prognosis and quality of life of the patients. Whether adiponectin is involved in malnutrition in stable COPD patients has not been confirmed.
【作者单位】：广州医科大学附属第三医院呼吸内科;
【基金】：广东省科技计划项目(编号:63090)
【分类号】：R563.9

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