脉冲振荡技术结合支气管舒张试验在老年慢性阻塞性肺疾病中的应用

发布时间：2018-04-20 22:31

本文选题：肺通气功能 + 慢性阻塞性肺疾病　；参考：《南京医科大学学报(自然科学版)》2014年02期

【摘要】：目的:探讨脉冲振荡技术(IOS)结合支气管舒张试验(BDT)在老年慢性阻塞性肺疾病(COPD)中的应用价值。方法:选择55例老年稳定期COPD患者进行支气管舒张试验,比较用药前后常规肺功能与IOS测定结果。结果:BDT用药后的用力肺活量占预计值百分比(FVC%pred)、1秒钟用力呼气容积占预计值百分比(FEV1%pred)、呼出肺活量中间50%时的平均用力呼气流量占预计值百分比(FEF25%~75%pred)、呼出肺活量50%时的用力呼气流量占预计值百分比(FEF50%pred)、呼出肺活量75%时的用力呼气流量占预计值百分比(FEF75%pred)结果均明显高于用药前,差异有统计学意义;BDT用药后患者IOS各参数均明显低于对照组,差异有统计学意义;气道总阻力改善率(R5Chg)与1秒钟用力呼气容积改善率(FEV1Chg)呈负相关;低频电抗面积改善率(AXChg)与用力肺活量改善率(FVCChg)、FEV1Chg、呈正相关;周边气道粘性阻力改善率(R5~20Chg)与呼出肺活量50%时的用力呼气流量改善率(FEF50Chg)呈负相关。结论:IOS有可能成为老年COPD患者行BDT时肺通气功能检查的必要补充手段;BDT可用于指导老年COPD患者支气管扩张药的选择及疗效评定。
[Abstract]:Objective: to investigate the application value of pulsed oscillatory technique (IOS) combined with bronchodiastolic test (BDTT) in elderly patients with chronic obstructive pulmonary disease (COPD). Methods: bronchodiastolic test was performed in 55 elderly patients with stable COPD. The results of routine lung function and IOS were compared before and after treatment. Results the percentage of forced vital capacity (RVV) to the predicted value after the administration of FVCpredt and the percentage of forced expiratory volume in one second as a percentage of the predicted value FEV1predr were compared with that of FEV1 predder, and the mean forced expiratory flow (FFEF) at 50 in the middle of vital capacity as a percentage of the predicted value was compared with that of FEF25 / 75predn, and the vital capacity at 50 minutes after exhalation. The percentage of forced expiratory flow to predicted value and the percentage of forced expiratory flow to predicted value when exhaling vital capacity 75 were significantly higher than those before medication. The IOS parameters were significantly lower than those in the control group, and the improvement rate of total airway resistance (R5Chg) was negatively correlated with the improvement rate of forced expiratory volume in 1 second and FEV1Chg. The improvement rate of low frequency reactance area (AXChg) was positively correlated with the improvement rate of forced vital capacity (FVC) and FEV1Chg, and the improvement rate of peripheral airway viscosity resistance (R520Chg) was negatively correlated with the improvement rate of forced expiratory flow (FEF50Chg) at the time of exhaling vital capacity (50%). Conclusion\\\% iOS\\\
【作者单位】：南京医科大学第一附属医院老年呼吸科;
【基金】：江苏省高校优势学科建设工程(JX10231801)
【分类号】：R563.9

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