肾损伤对慢性阻塞性肺疾病急性加重及住院的影响

发布时间：2018-04-26 16:56

本文选题：肺疾病 + 慢性阻塞性　；参考：《重庆医学》2017年21期

【摘要】：目的探讨慢性肾脏病(CKD)对慢性阻塞性肺疾病(COPD)急性加重(AECOPD)及住院的影响。方法选取2011年1月至2013年6月该院经临床确诊的COPD合并CKD患者50例(观察组),及未合并CKD的COPD患者50例(对照组)。回顾性分析患者1年内的肺功能、运动耐力及住院情况等资料,并进行比较。结果观察组病死率、AECOPD总发生率及重度AECOPD发生率、住院率、住院时间、自我评估测试(CAT)评分、改良英国医学研究理事会(mMRC)呼吸困难指数、C反应蛋白(CRP)及血肌酐水平均高于对照组,差异均有统计学意义(P0.05);观察组第1秒用力呼气容积(FEV1)占预计值百分比(FEV1%pred)、6min步行试验(6MWD)及肌酐清除率均低于对照组,差异均有统计学意义(P0.05);两组FEV1/用力肺活量(FVC)比值比较,差异无统计学意义(P0.05)。结论确诊后1年COPD合并CKD患者的病情较未合并CKD患者明显加重,预后较差。
[Abstract]:Objective to investigate the effect of chronic kidney disease (CKD) on acute exacerbation and hospitalization of chronic obstructive pulmonary disease (COPD). Methods from January 2011 to June 2013, 50 patients with COPD combined with CKD were selected from January 2011 to June 2013 (observation group) and COPD group (50 cases without CKD) (control group). The data of lung function, exercise endurance and hospitalization were retrospectively analyzed and compared. Results the mortality rate, total incidence of AECOPD, duration of hospitalization, self-assessment test score, dyspnea index of modified British Medical Research Council (MRC) and serum creatinine levels in the observation group were higher than those in the control group. The percentage of forced expiratory volume (FEV1) and creatinine clearance were significantly lower in the observation group than in the control group (P 0.05), and the ratio of forced expiratory volume and FEV1 in the observation group was significantly lower than that in the control group (P 0.05), and the ratio of forced vital capacity of the two groups was higher than that of the control group. The difference was not statistically significant (P 0.05). Conclusion one year after diagnosis, the patients with COPD combined with CKD are worse than those without CKD, and the prognosis is worse.
【作者单位】：首都医科大学附属北京朝阳医院呼吸与危重症医学科/北京呼吸疾病研究所;
【分类号】：R563.9

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