抑郁症合并肺部感染患者皮质醇、5-羟色胺及炎症因子变化与相关性研究

发布时间：2018-04-29 07:23

  本文选题：抑郁症 + 肺部感染　； 参考：《中华医院感染学杂志》2017年02期

【摘要】：目的探讨抑郁症合并肺部感染患者皮质醇、5-羟色胺及炎症因子变化及相关性,为临床诊治提供参考。方法选取2014年8月-2015年10月在医院诊治的抑郁症患者60例为抑郁症组,其中并发肺部感染与单纯抑郁症无肺部感染患者各30例,同时选取健康体检的正常人群60例为对照(对照组),对比各组间血清白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、皮质醇及5-羟色胺、C-反应蛋白(CRP)水平。结果抑郁组患者CRP、IL-6、TNF-α、皮质醇水平高于对照组,5-羟色胺低于对照组,比较差异有统计学意义(P0.05);抑郁组并发肺部感染患者CRP、IL-6、TNF-α、皮质醇水平分别为(13.84±4.90)mg/L、(16.12±4.02)ng/L、(17.92±2.50)ng/L、(191.14±60.13)μg/L,高于非肺部感染患者(5.82±2.81)mg/L、(5.25±0.30)ng/L、(5.01±1.77)ng/L、(132.04±31.52)μg/L,5-羟色胺为(16.72±5.55)μg/L低于非肺部感染患者(31.84±6.91)μg/L,差异有统计学意义(P0.05);中重度抑郁症患者CRP、IL-6、TNF-α、皮质醇水平高于轻度患者,5-羟色胺低于轻度患者,差异有统计学意义(P0.05)。结论抑郁症患者皮质醇及炎症因子明显升高,5-羟色胺有所下降,与肺部感染及抑郁严重程度密切相关。
[Abstract]:Objective to investigate the changes and correlation of cortisol 5-hydroxytryptamine and inflammatory factors in patients with depression complicated with pulmonary infection, and to provide reference for clinical diagnosis and treatment. Methods from August 2014 to October 2015, 60 patients with depression were selected as depression group, including 30 patients with pulmonary infection and 30 patients with simple depression without pulmonary infection. At the same time, 60 healthy people were selected as control group (control group). The serum levels of interleukin-6 (IL-6), tumor necrosis factor 伪 (TNF- 伪), cortisol and serotonin C reactive protein (CRP) were compared. Results the levels of TNF- 伪 and cortisol in the depression group were higher than those in the control group, and the levels of serotonin in the depression group were lower than those in the control group. 姣旇緝宸�寮傛湁缁熻�″�︽剰涔�(P0.05);鎶戦儊缁勫苟鍙戣偤閮ㄦ劅鏌撴偅鑰匔RP,IL-6,TNF-伪,鐨�璐ㄩ唶姘村钩鍒嗗埆涓�(13.84卤4.90)mg/L,(16.12卤4.02)ng/L,(17.92卤2.50)ng/L,(191.14卤60.13)渭g/L,楂樹簬闈炶偤閮ㄦ劅鏌撴偅鑰，

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