慢性阻塞性肺疾病急性发作期患者血尿酸肌酐比与肺弥散功能相关性分析

发布时间：2018-05-01 17:00

本文选题：血尿酸肌酐比 + 弥散功能　；参考：《中国实用内科杂志》2014年S1期

【摘要】：目的了解慢性阻塞性肺疾病急性发作期(AECOPD)患者血尿酸肌酐比与肺弥散功能的相关性。方法选取我科2012年3月至2014年3月因AECOPD住院患者共302名进行回顾性分析,排除痛风、肾功能不全和明显肺部感染者,收集患者临床资料、动脉血气分析、肾功能、肺通气功能及弥散功能指标,并进行相关性分析。结果患者血尿酸肌酐比与DLCO、氧合指数、FEV1实/预%、FVC实/预%存在负相关,相关系数分别为-0.62,-0.57,-0.32,-0.38,P值均0.05,其中与DLCO、氧合指数相关性最为明显,提示肺交换功能越差、缺氧程度越重,血尿酸肌酐比升高越明显。结论血尿酸肌酐比与DLCO有较高的关联性,当AECOPD患者无法行肺弥散功能检测时,血尿酸肌酐比可作为一较好的评估肺弥散功能的参考指标。
[Abstract]:Objective to investigate the correlation between serum uric acid creatinine ratio and pulmonary diffusion function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A retrospective analysis of 302 inpatients with AECOPD from March 2012 to March 2014 was carried out to exclude gout, renal insufficiency and obvious pulmonary infection, and to collect clinical data, arterial blood gas analysis and renal function. Pulmonary ventilation function and diffusive function were analyzed. Results there was a negative correlation between serum creatinine ratio and DLCO, FEV1 / FVC /%, the correlation coefficients were -0.62 ~ 0.57 ~ (-0.32) ~ (-0.38) P, respectively. The correlation between the ratio of serum creatinine and DLCO-oxygenation index was the most obvious, which indicated that the worse the pulmonary exchange function, the more severe the degree of hypoxia. The higher the serum creatinine ratio was, the more obvious it was. Conclusion there is a high correlation between serum creatinine ratio and DLCO. When AECOPD patients are unable to measure pulmonary diffusive function, serum uric acid creatinine ratio can be used as a reference index to evaluate pulmonary diffusive function.
【作者单位】：广州市第一人民医院呼吸内科;
【分类号】：R563.9

【相似文献】