血清IMA水平对COPD病情的评估

发布时间：2018-05-01 17:25

本文选题：肺疾病 + 慢性阻塞性　；参考：《重庆医学》2017年19期

【摘要】：目的探讨血清缺血修饰清蛋白(IMA)在慢性阻塞性肺疾病(COPD)病情评估中的价值。方法选取2015年9月至2016年3月在该院诊治的COPD患者81例纳入COPD组(急性加重期50例,稳定期31例),同时收集30例非COPD的志愿者作为对照组;测定两组血清IMA水平并进行比较,分析COPD患者血清IMA水平与血清肌红蛋白(MYO)、肌钙蛋白T(TNT)、C反应蛋白(CRP)水平及全血白细胞(WBC)计数的相关性,绘制受试者工作特征(ROC)曲线,分析血清IMA水平在COPD的诊断价值。结果 COPD组血清IMA水平明显高于对照组[84.1(79.1,88.5)U/Lvs.73.1(70.2,75.1)U/L],急性加重期COPD患者血清IMA水平明显高于稳定期患者[85.5(82.3,89.4)U/L vs.78.1(75.9,83.0)U/L],急性加重期和稳定期COPD患者血清IMA水平均明显高于对照组,差异均有统计学意义(P0.05)。COPD患者血清IMA水平与血清MYO水平呈明显正相关(r=0.554,P=0.00);ROC曲线表明,当取截断值为76.55U/mL时,IMA诊断COPD的灵敏度为88.5%,特异度为80.0%,ROC曲线下面积为0.88。结论血清IMA水平在COPD病情评估方面有较好的临床价值,值得扩大样本进一步研究。
[Abstract]:Objective to investigate the value of serum ischemia modified albumin (IMA) in the evaluation of chronic obstructive pulmonary disease (COPD). Methods 81 COPD patients treated in our hospital from September 2015 to March 2016 were enrolled in COPD group (acute exacerbation 50 cases, stable 31 cases) and 30 non-COPD volunteers as control group, the serum IMA levels were measured and compared between the two groups. To analyze the correlation between serum IMA level and serum myoglobin (My), troponin C reactive protein (COPD) and WBC count in patients with COPD, to draw the operating characteristics curve of subjects and to analyze the diagnostic value of serum IMA level in COPD. Results the level of serum IMA in COPD group was significantly higher than that in control group [88.5U / L + 88.5U / L], and the serum IMA level in patients with acute exacerbation was significantly higher than that in stable patients [85.5 / 79.1U / L + 88.9U / L], and the level of serum IMA in patients with acute exacerbation and stable COPD was significantly higher than that in the control group (P < 0.05), and the serum IMA level in patients with acute exacerbation and stable COPD was significantly higher than that in patients with acute exacerbation and stable COPD. There was a significant positive correlation between the serum IMA level and the serum MYO level in patients with 76.55U/mL. The results showed that when the truncation value was 76.55U/mL, the sensitivity of COPD was 88. 5%, the specificity was 80. 0% and the area under the ROC curve was 0. 88. Conclusion Serum IMA level has good clinical value in the evaluation of COPD, and it is worthy of further study.
【作者单位】：重庆医科大学附属第一医院检验科;
【分类号】：R563.9

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