纳洛酮联合无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床观察

发布时间：2018-05-02 01:57

本文选题：纳洛酮 + 无创正压通气　；参考：《广东医学》2017年12期

【摘要】：目的探究纳洛酮联合无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的临床疗效。方法选取COPD合并呼吸衰竭患者97例,按照随机数表法分为对照组与观察组,对照组接受NIPPV治疗,观察组接受纳洛酮联合NIPPV治疗。比较两组治疗效果、血气分析指标及不良反应发生率。结果治疗后两组患者血气分析结果均较前有所改善,与治疗前相比差异有统计学意义(P0.05);治疗后观察组患者血气分析结果较对照组改善更为明显,两组比较差异有统计学意义(P0.05)。观察组患者气管插管率及病死率较对照组低,住院时间比对照组短,差异有统计学意义(P0.05)。观察组治疗总有效率为81.6%,明显高于对照组的62.5%,两组比较差异有统计学意义(P0.05)。两组患者不良反应发生率差异无统计学意义(P0.05)。结论纳洛酮联合NIPPV治疗COPD合并呼吸衰竭有较好的临床效果,能有效改善肺功能,且安全无明显不良反应,值得临床推广运用。
[Abstract]:Objective to investigate the clinical effect of naloxone combined with noninvasive positive pressure ventilation (NIPPVV) in the treatment of chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods 97 patients with COPD complicated with respiratory failure were divided into control group and observation group according to random number method. The control group received NIPPV and the observation group received naloxone combined with NIPPV. The therapeutic effect, blood gas analysis index and adverse reaction rate were compared between the two groups. Results after treatment, the results of blood gas analysis in the two groups were improved, and the difference was statistically significant compared with that before treatment, and the results of blood gas analysis in the observation group were more obvious than those in the control group after treatment, and the difference between the two groups was statistically significant. The rate of tracheal intubation and fatality rate in the observation group were lower than those in the control group, and the hospitalization time was shorter than that in the control group (P 0.05). The total effective rate of treatment in the observation group was 81.6, which was significantly higher than that in the control group (62.5%). The difference between the two groups was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion Naloxone combined with NIPPV has good clinical effect in treating COPD with respiratory failure and can effectively improve pulmonary function.
【作者单位】：广州市花都区花山镇卫生院内科;
【分类号】：R563.8;R563.9

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