止嗽化痰胶囊联合左氧氟沙星治疗慢性支气管炎急性发作的临床观察

发布时间：2018-05-04 18:02

  本文选题：止嗽化痰胶囊 + 左氧氟沙星　； 参考：《中药药理与临床》2017年01期

【摘要】：目的:研究止嗽化痰胶囊联合左氧氟沙星对慢性支气管炎急性发作患者的治疗效果。方法:回顾性分析2014年8月~2016年4月在郑州大学附属郑州中心医院接受治疗的80例慢性支气管炎急性发作患者的临床资料,根据其治疗方式分为左氧氟沙星组(对照组)和止嗽化痰胶囊联合左氧氟沙星治疗组(观察组)。观察两组治疗前后症状积分、肺功能、炎症细胞因子水平和副作用发生情况。结果:(1)治疗后观察组咳嗽、咯痰和肺部听诊积分分别为(0.75±0.15、0.66±0.08和0.61±0.17)分,均明显低于对照组(1.18±0.21、1.12±0.16和1.14±0.11)分。(2)治疗后观察组用力肺活量(FVC)、一秒用力呼气容积(FEV1)、FEV1/FVC、最大呼气中期流量(MMEF)和呼气流量峰值(PEF)水平分别为(3.24±0.47L、3.05±0.43L、74.16±8.35%、3.11±0.67L/s、7.32±0.57L/s),均明显高于对照组(2.25±0.52L、2.02±0.35L、60.21±7.48%、2.09±0.43L/s、6.18±0.43L/s)。(3)治疗后观察组白细胞介素-8(IL-8)、超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)水平分别为(108.78±5.02pg/ml、12.02±1.08mg/L和19.48±1.0ng/L),均明显低于对照组(197.32±4.24pg/ml、15.14±1.12mg/L和24.35±1.29ng/L)。(4)两组患者均未出肝肾功能异常。结论:止嗽化痰胶囊联合左氧氟沙星对慢性支气管炎急性发作有较好的治疗效果,可明显改善患者的症状和肺功能。
[Abstract]:Objective: to study the therapeutic effect of Zhisou Huatan capsule combined with levofloxacin on acute attack of chronic bronchitis. Methods: the clinical data of 80 patients with acute exacerbation of chronic bronchitis who were treated in Zhengzhou Central Hospital affiliated to Zhengzhou University from August 2014 to April 2016 were analyzed retrospectively. According to its treatment method, it was divided into levofloxacin group (control group) and Zhisou Huatan capsule combined with levofloxacin treatment group (observation group). Symptom score, pulmonary function, inflammatory cytokines and side effects were observed before and after treatment. Results the scores of cough, sputum and lung auscultation were 0.75 卤0.150.66 卤0.08 and 0.61 卤0.17, respectively. 鍧囨槑鏄句綆浜庡�圭収缁�(1.18卤0.21,1.12卤0.16鍜，

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