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双重氧化酶与呼吸系统关系的研究进展

发布时间:2018-05-05 16:58

  本文选题:同源异构体 + 气道上皮细胞 ; 参考:《中国呼吸与危重监护杂志》2016年01期


【摘要】:正氧化应激是导致呼吸系统疾病的一个主要原因。近来越来越多的证据表明NADPH氧化酶在呼吸系统产生活性氧(ROS)过程中发挥重要作用。NADPH氧化酶体系现在已基本确定7种氧化酶(NOX)同源异构体,包括NOX1-5、DUOX1、DUOX2,两种组织亚基(p47phox、NOXO1),两种激活亚基(p67phox、NOXA1),以及两种双重氧化酶(DUOX)特定的成熟因素(DUOXA1和DUOXA2)~[1]。NOX
[Abstract]:Positive oxidative stress is a major cause of respiratory diseases. Recently, there has been more and more evidence that NADPH oxidase plays an important role in the production of reactive oxygen species (Ros) in respiratory system. These include NOX1-5, DUOX1, DUOX2, two tissue subunits, p47phox, two activated subunits, p67phox, NOXA1, and two specific maturation factors, DUOXA1 and DUOXA2OX1 ~ [1] .NOX, as well as two specific maturation factors, DUOXA1 and DUOXA2UXA2OX1, as well as two specific maturation factors, DUOXA1 and DUOXA2N ~ [1] .NOX.
【作者单位】: 广州军区广州总医院呼吸内科;
【基金】:国家自然科学基金面上项目(编号:81370173)
【分类号】:R56


本文编号:1848510

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