急性心肌梗死患者肺炎衣原体感染及相关性调查分析

发布时间：2018-05-07 08:51

本文选题：肺炎衣原体感染 + 急性心肌梗死　；参考：《中华医院感染学杂志》2017年11期

【摘要】：目的观察急性心肌梗死患者肺炎衣原体感染情况,探讨肺炎衣原体感染与急性心肌梗死发生的关系。方法选取2015年1月-2016年1月医院收治的急性心肌梗死患者124例为心梗组,同时选择健康体检者120名为对照组,检测两组研究者血清肺炎衣原体IgG抗体、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、可溶性血管细胞黏附分子-1(sVCAM-1)和超敏C-反应蛋白(hs-CRP)水平,采用logistic回归分析急性心肌梗死的影响因素。结果心梗组肺炎衣原体感染阳性率和浓度分别为60.5%和(64.17±15.62)RU,均明显高于对照组24.2%和(17.89±8.56)RU,差异有统计学意义(P0.05);多元logistic回归分析显示,低密度脂蛋白胆固醇和肺炎衣原体感染是影响急性心肌梗死发生的独立危险因素,差异有统计学意义(P0.05);心梗组肺炎衣原体抗体阳性者血清IL-6、IL-18、VCAM-1和hs-CRP水平分别为(75.13±15.27)pg/ml、(52.28±14.32)pg/ml、(38.43±7.81)nmol/L和(21.33±9.87)mg/L,明显高于抗体阴性者(24.45±6.72)pg/ml、(25.63±7.35)pg/ml、(5.43±2.17)nmol/L和(2.05±1.02)mg/L差异有统计学意义(P0.05)。结论肺炎衣原体感染是急性心肌梗死患者发生的独立危险因素之一,其可能通过炎症反应,参与急性心肌梗死的病理过程。
[Abstract]:Objective to investigate the relationship between chlamydia pneumoniae infection and acute myocardial infarction in patients with acute myocardial infarction. Methods 124 patients with acute myocardial infarction treated in our hospital from January 2015 to January 2016 were selected as myocardial infarction group and 120 healthy persons as control group. Serum chlamydia pneumoniae IgG antibody was detected in two groups. The levels of IL-6, IL-18, soluble vascular cell adhesion molecule-1 (VCAM-1) and hypersensitive C-reactive protein (hs-CRP) were analyzed by logistic regression analysis. Results the positive rate and concentration of chlamydia pneumoniae infection in myocardial infarction group were 60.5% and 64.17 卤15.62%, respectively, which were significantly higher than those in control group (24.2% and 17.89 卤8.56 rugs). Low density lipoprotein cholesterol and chlamydia pneumoniae infection are independent risk factors for acute myocardial infarction. The serum levels of IL-6, IL-18, VCAM-1 and hs-CRP in patients with positive chlamydia pneumoniae antibody were 75.13 卤15.27pg / ml, 52.28 卤14.32pg / ml, 38.43 卤7.81)nmol/L and 21.33 卤9.87mg / L, respectively, which were significantly higher than those in patients with negative antibodies (24.45 卤6.72g / ml, 25.63 卤7.35hg / ml, 5.43 卤2.17)nmol/L and 2.05 卤1.02)mg/L, respectively). Conclusion Chlamydia pneumoniae infection is one of the independent risk factors in patients with acute myocardial infarction. It may participate in the pathological process of acute myocardial infarction through inflammatory reaction.
【作者单位】：河南省人民医院急诊内科病房;河南省人民医院急诊ICU;河南大学第一附属医院;
【分类号】：R542.22;R563.1

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