热毒宁注射液联合头孢哌酮钠舒巴坦钠注射剂治疗慢性阻塞性肺疾病合并肺部感染的临床研究

发布时间：2018-05-08 08:54

本文选题：热毒宁注射液 + 头孢哌酮钠舒巴坦钠注射剂　；参考：《中国临床药理学杂志》2017年15期

【摘要】：目的观察热毒宁注射液联合头孢哌酮钠舒巴坦钠注射剂治疗慢性阻塞性肺疾病(COPD)合并肺部感染的临床疗效和安全性。方法将68例COPD合并肺部感染患者随机分为对照组34例与试验组34例。对照组给予静脉滴注盐酸莫西沙星氯化钠注射液250 m L,qd,注射用头孢哌酮钠舒巴坦钠静脉滴注1.0g,bid;试验组在对照组治疗的基础上,给予静脉滴注热毒宁注射液20 m L,qd。2组患者均治疗10 d。比较2组患者的临床疗效和药物不良反应发生情况。结果治疗后,试验组和对照组总有效率分别为94.12%(32/34例)和70.59%(24/32例),差异有统计学意义(P0.05)。试验组出现的主要药物不良反应类型为头痛、胃肠道反应、皮疹,对照组出现的主要药物不良反应类型为头痛、肝酶轻度上升、胃肠道反应、皮疹,试验组和对照组的药物不良反应发生率分别为8.82%和14.71%,差异无统计学意义(P0.05)。结论热毒宁注射液联合头孢哌酮钠舒巴坦钠注射剂治疗COPD的临床疗效显著,安全性高。
[Abstract]:Objective To observe the clinical efficacy and safety of hot venin injection combined with cefoperazone sodium sulbactam sodium injection in the treatment of chronic obstructive pulmonary disease (COPD) with pulmonary infection. Methods 68 cases of COPD combined with pulmonary infection were randomly divided into control group (34 cases) and experimental group (34 cases). The control group was given intravenous drip of moxifloxacin sodium chloride injection. The injection of 250 m L, QD, Cefoperazone Sodium and Sulbactam Sodium for Injection intravenous drip 1.0g, bid; on the basis of the control group, the experimental group was given intravenous drip of hot venin injection 20 m L, and the patients in group qd.2 were treated with 10 d. to compare the clinical efficacy and the occurrence of adverse drug reactions in the 2 groups. Results after treatment, the total effective rate of the test group and the control group was effective. The differences were 94.12% (32/34) and 70.59% (24/32) respectively. The differences were statistically significant (P0.05). The main types of adverse drug reactions in the test group were headache, gastrointestinal reaction, rash, and the main types of adverse drug reactions in the control group were headache, liver enzyme mild up, gastrointestinal reaction, rash, test group and control group. The incidence rate was 8.82% and 14.71% respectively, the difference was not statistically significant (P0.05). Conclusion the clinical efficacy of the combined injection of cefoperazone sodium and sulbactam sodium with cefoperazone sodium injection was significant and safe in the treatment of COPD.

【作者单位】：玉林市第三人民医院呼吸内科;玉林市第一人民医院呼吸科;衢州市人民医院呼吸科;
【基金】：浙江省医药卫生科技计划基金资助项目(2011KYB160)
【分类号】：R563

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