盐酸氨溴索治疗昏迷患者肺部感染的临床研究

发布时间：2018-05-08 23:19

本文选题：盐酸氨溴索 + 昏迷患者　；参考：《中华医院感染学杂志》2014年14期

【摘要】：目的探讨盐酸氨溴索治疗昏迷患者肺部感染的临床效果,以期提高临床治疗水平,降低感染率。方法选取2011年8月-2013年5月118例昏迷发生肺部感染患者为研究对象,将其随机分为两组,对照组60例采用基础治疗,观察组58例予以基础治疗加盐酸氨溴索雾化吸入和静脉滴注治疗,比较两组治疗后临床效果;采用SPSS16.0软件进行统计分析。结果对照组治愈率为21.67%、显效率为35.00%、有效率为16.67%、总有效率为73.33%;观察组治愈率为65.52%、显效率为20.69%、有效率为8.62%、总有效率为94.83%,两组比较差异有统计学意义(P0.05);两组患者住院时间、咳嗽缓解时间、体温恢复正常时间、昏迷好转时间、胸片阴影吸收时间、体征恢复时间、血常规正常时间比较差异有统计学意义(P0.05);两组治疗后第7、10、14天在无创血氧饱和度(SaO2)和血氧分压(PO2)比较差异有统计学意义(P0.05)。结论盐酸氨溴索治疗昏迷并肺部感染临床效果显著,安全性高。
[Abstract]:Objective to investigate the clinical effect of ambroxol hydrochloride in the treatment of pulmonary infection in coma patients in order to improve the clinical treatment level and reduce the infection rate. Methods from August 2011 to May 2013, 118 patients with pulmonary infection in coma were randomly divided into two groups. 60 patients in control group were treated with basic therapy. 58 cases in the observation group were treated with basic therapy, atomization inhalation of ambroxol hydrochloride and intravenous drip, and the clinical effects were compared between the two groups, and the statistical analysis was carried out by SPSS16.0 software. Results in the control group, the cure rate was 21.67, the markedly effective rate was 35.00, the effective rate was 16.67 and the total effective rate was 73.33; in the observation group, the cure rate was 65.52, the markedly effective rate was 20.6920. The effective rate was 8.62 and the total effective rate was 94.83. The difference between the two groups was statistically significant (P0.05). Cough relief time, body temperature recovery time, coma improvement time, chest film shadow absorption time, physical sign recovery time, There was significant difference in the normal time of blood routine between the two groups (P 0.05), and there was a significant difference between the two groups in the non-invasive oxygen saturation (SaO2) and the blood oxygen partial pressure (PO2) on the 14th day after treatment (P 0.05). Conclusion Ambroxol hydrochloride is effective and safe in the treatment of coma and pulmonary infection.
【作者单位】：南阳市中心医院神经内科;
【基金】：河南省卫生厅专项支持计划基金资助项目(HW-2010B-048)
【分类号】：R563.1

【参考文献】