支气管舒张剂治疗无效的咳嗽变异性哮喘患者炎性介质水平和炎性细胞百分比的检测及其意义

发布时间：2018-05-09 17:14

本文选题：白细胞介素 + 中性粒细胞　；参考：《吉林大学学报(医学版)》2016年02期

【摘要】：目的:检测咳嗽变异性哮喘(CVA)患者炎性介质水平和炎性细胞百分比,阐明白细胞介素8(IL-8)和中性粒细胞在支气管舒张剂治疗无效的CVA发病中的作用。方法:随机选择60例CVA患者,分为支气管舒张剂治疗无效组(n=30)和支气管舒张剂治疗有效组(n=30),同时选取健康人群作为正常对照组(n=30)。检测3组研究对象诱导痰上清液中IL-8水平和嗜酸性粒细胞阳离子蛋白(ECP)水平,观察诱导痰中细胞学分类,记录咳嗽症状评分。结果:支气管舒张剂治疗无效组患者诱导痰中IL-8水平明显高于支气管舒张剂治疗有效组和正常对照组(P0.05);诱导痰中ECP水平明显低于支气管舒张剂治疗有效组(P0.05),但与正常组水平接近(P0.05);支气管舒张剂治疗无效组患者诱导痰中中性粒细胞百分比明显高于支气管舒张剂治疗有效组和正常对照组(P0.05);支气管舒张剂治疗无效组患者咳嗽症状评分与诱导痰中IL-8水平呈正相关关系(r=0.764,P0.01),并与其中性粒细胞百分比呈正相关关系(r=0.889,P0.01)。结论:IL-8和中性粒细胞参与支气管舒张剂治疗无效的CVA的发病,可加重气道炎症和气道高反应性,使咳嗽症状加重;在临床上IL-8和中性粒细胞检测可作为CVA诊断、严重程度及疗效判定的辅助手段。
[Abstract]:Aim: to detect the level of inflammatory mediators and the percentage of inflammatory cells in patients with cough variant asthma (CVA) and to elucidate the role of interleukin-8 (IL-8) and neutrophil in the pathogenesis of CVA with ineffective bronchodiastolic therapy. Methods: sixty patients with CVA were randomly divided into two groups: bronchodiastolic group (n = 30), bronchodiastolic group (n = 30) and normal control group (n = 30). The levels of IL-8 and eosinophil cationic protein in the supernatant of induced sputum were measured. The cytological classification of induced sputum was observed and the cough symptom score was recorded. Results: the level of IL-8 in induced sputum in patients with ineffective bronchodiastolic therapy was significantly higher than that in the effective group treated with bronchodiastolic agent and normal control group (P0.05), and the level of ECP in induced sputum was significantly lower than that in the group treated with bronchodiastolic agent (P 0.05). The percentage of neutrophils in induced sputum in patients with ineffective bronchodiastolic therapy was significantly higher than that in the effective bronchodiastolic group and the normal control group. There was a positive correlation between symptom score and IL-8 level in induced sputum (P 0.01) and a positive correlation with the percentage of neutrophils. ConclusionTwo eight IL-8 and neutrophilic granulocytes are involved in the pathogenesis of CVA with no effect of bronchodiastolic agents, which can aggravate airway inflammation and airway hyperresponsiveness, and aggravate cough symptoms. IL-8 and neutrophil detection can be used as diagnosis of CVA in clinic. The degree of severity and the auxiliary means of evaluating the curative effect.
【作者单位】：北华大学附属医院呼吸科;北华大学附属医院神经内科;北华大学附属医院药剂科;
【基金】：吉林省教育厅“十二五”科学技术研究项目资助课题(吉教科2013190)
【分类号】：R562.25

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