慢性阻塞性肺疾病患者心脏复极离散度与肺功能的关系研究

发布时间：2018-05-11 09:16

本文选题：肺疾病 + 慢性阻塞性　；参考：《中国全科医学》2014年16期

【摘要】：目的研究慢性阻塞性肺疾病(COPD)患者心脏复极离散度与肺功能的关系,并探讨其临床意义。方法纳入2012年1月—2013年6月我院156例COPD患者(COPD组)和64例体检正常者(对照组),行12导联体表心电图和超声心动图检查〔包括左室射血分数(LVEF)、左室内径(LVD)、左房内径(LAD)、右室内径(RVD)、右房内径(RAD)、肺动脉压(PAP)〕,计算复极离散度〔包括空间离散度(QTd)和短时程离散度(STVQT)〕,并行肺功能检测〔包括用力肺活量(FVC)和第1秒末用力呼气量(FEV1)〕和呼吸困难指数评级,比较两组之间的差异,分析复极离散度和肺功能的相关性。结果与对照组相比,COPD组的复极离散度较大:QTd〔(63±15)ms比(45±15)ms〕和STVQT〔(7.5±3.2)ms比(3.3±0.6)ms〕;心功能较差:LVEF〔(52±7)%比(58±9)%〕、RVD〔(31±6)mm比(23±5)mm〕和PAP〔(33±12)mm Hg比(24±7)mm Hg〕;肺功能较差:FVC〔(62±15)%比(95±5)%〕、FEV1〔(47±16)%比(98±8)%〕和FEV1/FVC〔(59±9)%比(80±10)%〕;呼吸困难指数较高:〔(2.6±1.6)级比(1.3±0.5)级〕;差异均有统计学意义(P0.01);心脏复极离散度与FEV1/FVC呈负相关:QTd(r=-0.52)和STVQT(r=-0.68)。结论 COPD患者心脏复极离散度显著增加,与肺功能相关,可能是患者心脏并发症增加的危险因素。
[Abstract]:Objective to study the relationship between cardiac repolarization dispersion and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods from January 2012 to June 2013, 156 patients with COPD in our hospital and 64 normal controls (control group) were enrolled for 12 lead electrocardiogram (ECG) and echocardiography (including left ventricular ejection fraction (LVEF), left ventricular diameter (LVD), left atrium (left atrium). Lad, RV, RAD, PAPP, Repolarization dispersion (including spatial dispersion / QTd) and short term dispersion (STVQT) were calculated, pulmonary function was measured (including forced vital capacity (FVCC) and forced expiratory volume (FEV1) at the end of the first second (FEV1) and dyspnea index rating was compared between the two groups. The correlation between repolarization dispersion and lung function was analyzed. Results compared with the control group, the dispersion of repolarization in the 15)ms group was greater than that in the control group (63 卤15)ms vs 45 卤15ms) and STVQT((7.5 卤3.2)ms was 3.3 卤0.6mgs, and the heart function was lower than that in the control group, the heart function was lower than that in the control group (52 卤7% vs 58 卤9 卤9 6)mm vs 23 卤5mm) and PAP((33 卤12)mm Hg = 24 卤7)mm Hg. The ratio of FEV1/FVC((59 卤9% to 卤10 ~ (5) and the ratio of FEV1/FVC((59 卤9% to 80 卤10 ~ (5) was higher than that of 2. 6 卤1.6). The difference was statistically significant (P < 0.01); the dispersion of cardiac repolarization was negatively correlated with FEV1/FVC (QTdtdr-0.52) and STVQTnr-0.68 (P < 0. 01), the difference was significant (P < 0. 01), and there was a negative correlation between the dispersion of cardiac repolarization and FEV1/FVC (P < 0. 01) and the ratio of FEV1/FVC((59 卤9% to 0. 80 卤10 ~ (5) (P < 0. 01), the difference was statistically significant (P < 0. 01), and there was a negative correlation between the dispersion of cardiac repolarization and FEV1/FVC (P < 0. 01). Conclusion Cardiac repolarization dispersion is significantly increased in patients with COPD, which is related to pulmonary function and may be a risk factor for the increase of cardiac complications in patients with COPD.
【作者单位】：新疆生产建设兵团第一师医院呼吸科;
【分类号】：R563.9

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