成年过敏性及非过敏性哮喘的临床特征分析

发布时间：2018-05-13 23:31

  本文选题：哮喘 + 过敏性　； 参考：《中国呼吸与危重监护杂志》2017年03期

【摘要】：目的探讨成年过敏性及非过敏性哮喘患者的临床特征及意义。方法连续纳入2014年10月至2016年6月于四川大学华西医院哮喘专病门诊初诊未治疗的成年哮喘患者,以抗原特异性IgE阳性或常见过敏原皮肤点刺试验阳性分为过敏性哮喘(AAS)组和非过敏性哮喘(NAAS)组,纳入性别、发病年龄、哮喘控制测试(ACT)评分、肺功能、气流受限类型、呼出气一氧化氮分数(FeNO)、体重指数、疾病严重程度等指标进行分析。结果共纳入131例患者。其中,AAS组72例,NAAS组59例。NAAS组FeNO水平为(51.1±32.6)ppb,与AAS组(69.1±41.7)ppb相比,差异有统计学意义(t= 2.762,P=0.007);NAAS组合并鼻炎(17/59)与AAS组合并鼻炎(48/72)相比,差异有统计学意义(χ~2=19.396,P=0.000);NAAS组中无气流受限(NAO)、可逆性气流受限(RAO)、不可逆性气流受限(IAO)分别为20例(33.9%)、22例(37.3%)、17例(28.8%),AAS组分别为37例(51.4%)、26例(36.1%)、9例(12.5%),两组比较差异有统计学意义(Z= 2.461,P=0.014);NAAS组中轻度间歇/持续型、中度持续型、重度持续型分别为20例(33.9%)、18例(30.5%)、21例(35.6%),AAS组分别为37例(51.4%)、19例(26.4%)、16例(22.2%),两组比较差异有统计学意义(Z= 2.115,P= 0.034);NAAS组发病年龄[(28.9±16.3)岁]、ACT评分[(15.6±4.1)分]、FEV1%pred[(67.64±22.81)%]、体重指数[(23.8±4.74)kg/m~2],与AAS组[分别为(25.5±15.0)岁,(16.7±4.2)分,(74.42±21.05)%,(22.5±4.1)kg/m~2]相比,差异均无统计学意义(P0.05)。结论与AAS相比,NAAS病情更重,合并鼻炎的较少,FeNO水平较低,发生IAO的比例更高。
[Abstract]:Objective to investigate the clinical features and significance of adult allergic and non-allergic asthma. Methods from October 2014 to June 2016, adult asthmatic patients who had not been treated at the clinic of asthma special disease, Huaxi Hospital, Sichuan University, were included in the study. Antigen-specific IgE positive or skin prick test positive of common allergens were divided into allergic asthma group and non-allergic asthma group, including gender, onset age, asthma control test score, pulmonary function, airflow limitation type. The exhaled nitric oxide score (FES), body mass index (BMI) and severity of disease were analyzed. Results 131 patients were included. The FeNO level in 72 cases of AAS group was 51.1 卤32.6ppb, which was significantly higher than that of AAS group (69.1 卤41.7)ppb). There was a significant difference between AAS group and AAS group (1759%) and AAS group combined with rhinitis group (48P / 72). The difference was statistically significant (蠂 ~ 2 / 2 ~ (19.396) P ~ (0.000) P ~ (0.000) = 20 cases (n = 20) with reversible airflow limitation (Rao), 20 cases with irreversible airflow limitation (IAO) = 22 cases (n = 37) with 28. 8AAS, and 37 cases with AAS group (n = 37). There were significant differences between the two groups (P = 2.461P0.01414N ~ (1). There were significant differences between the two groups in the control group (n = 26) and in the control group (P = 2.461P0.01414NAAS). The difference between the two groups was statistically significant (P = 2.461P0.01414NAAS, P = 2.461P0.01414). Medium or mild intermittent / persistent, Medium persistence, 閲嶅害鎸佺画鍨嬪垎鍒�涓�20渚，

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