慢性阻塞性肺疾病患者身体成分改变及合并肌肉减少症的影响因素研究

发布时间：2018-05-17 03:34

本文选题：肺疾病 + 慢性阻塞性　；参考：《中国全科医学》2017年28期

【摘要】：目的了解慢性阻塞性肺疾病(COPD)患者的身体成分改变,并探讨其合并肌肉减少症的影响因素。方法选取2016年9—12月在锦州医科大学附属第一医院就诊的COPD患者96例为病例组;另于同期在本院体检者中,选取性别、年龄与病例组相匹配的健康成年人52例为对照组。检测并比较两组身高、体质量、BMI及身体成分情况;根据欧洲老年人肌肉减少症工作组(EWGSOP)制定的标准,以骨骼肌指数、步速为判断是否合并肌肉减少症的指标,采用单因素Logistic回归分析和多元逐步Logistic回归分析探讨COPD合并肌肉减少症的影响因素。结果病例组男性体质量、BMI、全身肌肉量、躯干肌肉量、双上肢肌肉量、双下肢肌肉量、四肢肌肉量、去脂体质量、骨骼肌指数、去脂体质指数低于对照组男性,差异有统计学意义(P0.05);病例组女性体质量、BMI、全身肌肉量、躯干肌肉量、双上肢肌肉量、双下肢肌肉量、四肢肌肉量、去脂体质量、骨骼肌指数低于对照组女性,差异有统计学意义(P0.05)。病例组肌肉减少症发生率高于对照组,差异有统计学意义(P0.05)。单因素Logistic回归分析结果显示,年龄、病程、BMI是COPD合并肌肉减少症的影响因素(P0.05);多元逐步Logistic回归分析结果显示,年龄、长期吸烟史、病程、BMI是COPD合并肌肉减少症的影响因素(P0.05)。结论 COPD患者肌肉量和去脂体质量明显低于健康者;COPD患者易合并肌肉减少症,高龄、长期吸烟、病程长、低BMI是其危险因素。
[Abstract]:Objective to investigate the changes of body composition in patients with chronic obstructive pulmonary disease (COPD) and explore the influencing factors. Methods Ninety-six COPD patients in the first affiliated Hospital of Jinzhou Medical University from September to December 2016 were selected as the case group, and 52 healthy adults who were matched by sex, age and the case group were selected as the control group in the same period. The height, body mass, BMI and body composition of the two groups were measured and compared. According to the EWGSOP standard, the skeletal muscle index and step speed were used to determine whether or not to be associated with myopenia. Univariate Logistic regression analysis and multiple stepwise Logistic regression analysis were used to investigate the influencing factors of COPD with myopenia. Results in the case group, the body weight of BMI, the body muscle volume, the trunk muscle volume, the upper limb muscle volume, the lower limb muscle volume, the fat-free body mass, the skeletal muscle index and the fat free body mass index were lower than those in the control group. The difference was statistically significant (P 0.05). The body mass of women in the case group was lower than that in the control group, and the body mass, trunk muscle volume, double upper limb muscle volume, lower limb muscle volume, fat-free body mass and skeletal muscle index were lower than those in the control group. The difference was statistically significant (P 0.05). The incidence of myopenia in the case group was higher than that in the control group (P 0.05). Univariate Logistic regression analysis showed that age and course of disease were the influencing factors of COPD with myopenia, and multiple stepwise Logistic regression analysis showed that age, long smoking history and course of disease were the influencing factors of COPD with myopenia. Conclusion muscle volume and fat-free body mass in COPD patients were significantly lower than those in healthy controls. The risk factors were elderly, long-term smoking, long course of disease and low BMI.
【作者单位】：锦州医科大学研究生学院;锦州医科大学附属第一医院呼吸科;锦州医科大学第一临床学院;
【分类号】：R563.9

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