慢性阻塞性肺疾病血IL-16、IFN-γ、CXCR3和CRP的表达及临床意义

发布时间：2018-05-18 11:11

本文选题：肺疾病 + 慢性阻塞性　；参考：《实用医学杂志》2014年18期

【摘要】：目的:通过观察白介素-16(IL-16)、干扰素-γ(IFN-γ)、CXC趋化因子受体3(CXCR3)和CRP在慢性阻塞性肺疾病急性加重期(AECOPD)中的变化,探讨IL-16、IFN-γ、CXCR3和CRP在AECOPD中的表达及临床意义。方法:收集AECOPD患者103例,同时期的健康体检者20例,根据2013GOLD指南将AECOPD分为A组21例,B组30例,C组27例,D组25例。采用双抗体夹心酶联免疫吸附法(ELASA)检测外周血清中IL-16、IFN-γ和CXCR3的表达。结果:(1)与健康对照组相比,AECOPD患者IL-16、IFN-γ、CXCR3及CRP水平显著升高(P0.01),并随疾病的严重程度而显著升高;(2)与治疗前相比,AECOPD患者IL-16、IFN-γ、CXCR3及CRP水平在治疗后显著降低(P0.05),但仍高于健康对照组(P0.05);(3)AECOPD患者血清中IL-16、IFN-γ、CXCR3、CRP水平之间均存在显著相关性。结论:IL-16、IFN-γ和CXCR3在AECOPD中表达明显增加,治疗后下降,且与疾病严重程度相关,提示这三种因子可能与COPD的发生、发展有关。
[Abstract]:Objective: to investigate the expression and clinical significance of IL-16, IFN- 纬, CXC chemokine receptor (CXCR3) and CRP in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbation of chronic obstructive pulmonary disease (COPD), and to explore the expression and clinical significance of IL-16 IFN- 纬 CXCR3 and CRP in AECOPD. Methods: 103 cases of AECOPD and 20 cases of health examination were collected. According to 2013GOLD guidelines, AECOPD was divided into two groups: group A (21 cases), group B (30 cases), group C (27 cases) and group D (25 cases). Double antibody sandwich enzyme linked immunosorbent assay (Elisa) was used to detect the expression of IL-16 IFN- 纬 and CXCR3 in peripheral serum. Results compared with the healthy control group, the levels of IL-16, IFN- 纬, CXCR3 and CRP in AECOPD patients were significantly higher than those in the healthy controls, and the levels of IL-16, IFN- 纬, CXCR3 and CRP in AECOPD patients were significantly increased with the severity of the disease. The serum levels of IL-16, IFN- 纬, CXCR3 and CRP in patients with P0. 05 and AECOPD were significantly correlated. Conclusion the expression of IFN- 纬 and CXCR3 in AECOPD was significantly increased, decreased after treatment, and correlated with the severity of the disease, suggesting that these three factors may be related to the occurrence and development of COPD.
【作者单位】：徐州医学院附属医院呼吸科;
【基金】：徐州医学院附属医院科研基金(编号:2014104020)
【分类号】：R563.9

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