耐药肺结核的药物治疗方案优化探讨

发布时间：2018-05-20 12:48

本文选题：肺结核 + 耐药　；参考：《江苏医药》2014年23期

【摘要】：目的观察耐药肺结核病的临床治疗效果,探讨优化药物治疗方案。方法选择65例复治菌阳具有耐药性的病例,给予对氨基水杨酸异烟肼、利福喷丁、左氧氟沙星、乙胺丁醇、丙硫异烟胺、卷曲霉素方案治疗12个月后,观察痰菌总阴转率、病灶总吸收率、空洞闭合率,随访1年。结果痰菌总阴转率为62.30%,病灶总吸收率为80.33%,空洞均有明显的缩小或闭合,未出现新的空洞,空洞闭合率为39.34%。随访1年无一例复阳,病变尚有一定的吸收。结论治疗方案的痰菌总阴转率、病灶总吸收率、空洞闭合率均较高,有利于耐药肺结核病的治疗。
[Abstract]:Objective to observe the clinical effect of drug-resistant pulmonary tuberculosis and to explore the optimization of drug therapy. Methods Sixty-five patients with drug resistance were treated with isoniazid aminosalicylate, rifapentine, levofloxacin, ethambutanol, propylthiocarbamate and entramycin for 12 months, and the total negative rate of sputum was observed. The total absorption rate and cavity closure rate were followed up for 1 year. Results the total negative conversion rate of sputum was 62.30%, the total absorption rate of the lesion was 80.33, the cavity was obviously reduced or closed, no new cavity appeared, and the cavity closure rate was 39.34%. All cases were followed up for 1 year, and there was still some absorption of the lesion. Conclusion the total negative rate of sputum bacteria, the total absorption rate and the cavity closure rate of the treatment regimen are all higher, which is beneficial to the treatment of drug-resistant pulmonary tuberculosis.
【作者单位】：南京市胸科医院药学部;南京市胸科医院结核科;
【分类号】：R521

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