老年下呼吸道感染患者痰分离真菌种类及药物敏感性

发布时间：2018-05-21 02:16

本文选题：亚高原 + 老年　；参考：《中国感染控制杂志》2016年03期

【摘要】：目的了解老年患者下呼吸道痰标本中真菌种类分布及药物敏感性,为预防真菌感染及针对性诊治提供依据。方法收集2010年1月—2014年10月云南亚高原地区3所医院老年患者下呼吸道标本分离的真菌,对其进行鉴定和药物敏感性试验。结果 1 887株真菌中,白假丝酵母菌最多,占65.18%,同时,分离出毛霉菌属(0.69%)、构巢曲霉菌(0.16%)等少见菌株;分离的菌株对制霉菌素、两性霉素B和伊曲康唑的敏感率较高,分别为100.00%、90.14%和88.98%;对氟康唑和咪康唑的耐药率较高,分别为34.29%和36.62%;5种常见酵母菌对制霉菌素均敏感,但白假丝酵母菌、光滑假丝酵母菌对氟康唑、咪康唑的耐药率达35.94%~40.88%,白假丝酵母菌对5-氟胞嘧啶的耐药率为19.51%。结论对老年人临床抗真菌治疗需要考虑真菌类别及药敏结果。
[Abstract]:Objective to investigate the distribution and drug sensitivity of fungi in lower respiratory tract sputum of elderly patients, and to provide evidence for prevention of fungal infection and targeted diagnosis and treatment. Methods from January 2010 to October 2014, fungi isolated from the lower respiratory tract of elderly patients in 3 hospitals in Yunnan Subplateau region were collected and identified and tested for drug sensitivity. Results among the 1 887 strains of fungi, Candida albicans was the most, accounting for 65.18.The rare strains, such as Mucor 0.69m, Aspergillus nestis 0.16m) were isolated, and the sensitive rates of the isolates to nystatin, amphotericin B and itraconazole were higher. The drug resistance rates of fluconazole and miconazole were 34.29% and 36.62%, respectively, which were sensitive to nystatin, but Candida albicans and Candida smooth were sensitive to fluconazole. The drug resistance rate of miconazole was 35.94. The resistance rate of Candida albicans to 5-fluorocytosine was 19.51. Conclusion the classification of fungi and drug sensitivity should be considered in the treatment of senile antifungal.
【作者单位】：中国人民解放军昆明总医院;云南省武警边防总队医院;中国人民武装警察部队云南省总队医院分院;成都军区联勤部卫生部信息中心;
【基金】：国家自然科学基金项目(81170316/H2501);国家自然科学基金项目(31200657)
【分类号】：R446.5;R56

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