冷哮证、热哮证与过敏原、食物不耐受的相关性分析

发布时间：2018-05-23 16:33

  本文选题：冷哮证 + 热哮证　； 参考：《山东中医药大学》2013年硕士论文

【摘要】：目的：本课题通过检测哮喘发作期小儿过敏原IgE及食物不耐受IgG，探讨其与中医分型冷哮证、热哮证的关系。 方法：选取山东中医药大学第二附属医院2012年3月至2013年3月间的住院哮喘患儿进行研究。患儿依据证型分为冷哮组30例，热哮组34例，都在治疗前检查特异性IgE、IgG。观察不同证型间过敏原和食物不耐受各种指标的阳性率及过敏原阳性种类均值。采用SPSS17.0统计软件，应用t检验和χ2检验，P0.05为两组间差异有显著性差异。 结果：本次研究共收集符合纳入标准病例64例，最大年龄10岁，最小年龄1.3岁。其中冷哮组患儿30例，男18，女12例，平均年龄4.916±2.63岁；热哮组患儿34例，男21例，，女13例，平均年龄4.709±2.31岁。两组患儿在男女年龄、性别差异P值均＞0.05，无显著性差异。所有64例患儿都检测两组敏原。有53例患儿（82.5%）检测出吸入性过敏原阳性，其中冷哮证组检出29例占96.7%，热哮证组检出24例占70.5%，两组对比有显著性差异；多种吸入性过敏原研究中，冷哮证组检出20例占66.7%，热哮证组检出12例占35.3%，对比有统计学差异（P＜0.05）；冷哮证组平均吸入性过敏原数2.47±1.358个，热哮证组平均1.500±1.503个，有显著性差异（P＜0.05）；食入组过敏原在两组证型间无显著性差异；食物不耐受各项比较两组间无显著性差异。 结论：1.冷哮组患儿中吸入组IgE抗体阳性率高于热哮组，两组比较有显著性差异，食入组IgE抗体阳性率在不同证型间比较无显著性差异。2.冷哮组患儿吸入组多种过敏原（≥2种）检出率高于热哮组，两组比较有显著性差异；食入组多种过敏原（≥2种）检出率冷哮组与热哮组比较无显著性差异。3.冷哮组患儿吸入组过敏原平均检出种类多于热哮组，两组比较有显著性差异。4.两组患儿共检出不耐受食物14种。各种食物不耐受阳性率在不同证型间比较无显著性差异。5.两组患儿食物不耐受IgG抗体检出阳性例数比较无显著性差异，多种（≥2种）食物不耐受检出阳性例数不同证型间比较无显著性差异。
[Abstract]:Objective: to investigate the relationship between IgE and food intolerance in children with asthma. Methods: children with asthma were selected from the second affiliated Hospital of Shandong University of traditional Chinese Medicine from March 2012 to March 2013. According to the syndrome type, the children were divided into cold asthma group (30 cases) and heat asthma group (34 cases). To observe the positive rate of allergen and food intolerance and the average value of allergen positive among different syndromes. Using SPSS17.0 statistical software, using t test and 蠂 2 test (P0.05), there was significant difference between the two groups. Results: a total of 64 cases were collected, the maximum age was 10 years old and the minimum age was 1.3 years old. There were 30 cases of cold asthma group (male 18, female 12, mean age 4.916 卤2.63), and 34 cases of heat asthma group (male 21, female 13, mean age 4.709 卤2.31). There was no significant difference between the two groups (P > 0.05). Two groups of allergens were detected in all 64 children. Among them, 29 cases were found to be positive in cold asthma group and 24 cases were 70.5 in heat wheezing syndrome group, there were significant differences between the two groups, among which, there were significant differences between the two groups in the study of multiple inhaled allergens, the results showed that the two groups were positive for inhaled allergens, and 96.7% were found in cold wheezing syndrome group and 24 cases in heat asthma syndrome group, and there were significant differences between the two groups. 20 cases were detected in cold asthma group and 12 cases in heat asthma group (P < 0.05), the average number of inhaled allergens was 2.47 卤1.358 in cold asthma group and 1.500 卤1.503 in heat asthma group. There was significant difference (P < 0.05), there was no significant difference between the two groups in the allergen of the ingestion group, and there was no significant difference in the items of food intolerance between the two groups. Conclusion 1. In cold asthma group, the positive rate of IgE antibody in inhalation group was higher than that in hot asthma group, there was significant difference between the two groups, and there was no significant difference in positive rate of IgE antibody between different syndromes. 2. The detection rate of multiple allergens (鈮

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