支气管哮喘患者凝血功能状态的临床分析

发布时间：2018-05-24 02:15

本文选题：哮喘 + 凝血功能　；参考：《新疆医科大学》2013年硕士论文

【摘要】：目的：通过对不同病程的哮喘患者凝血功能的比较，了解不同病程哮喘患者的凝血功能特点及是否存在差异，分析可能造成哮喘患者凝血功能改变的原因，为调节凝血功能的相关治疗应用于哮喘提供理论依据。方法：采用回顾性病例对照研究的方法，收集符合纳入及排除标准选取的222例患者的临床资料包括年龄、性别、病程长短及PT、INR、FIB、APTT、TT等数据。根据病程长短分为3组，，然后再将各组按年龄各分为老年组和非老年组，并对各组上述指标进行两两比较。结果：病程达10年以上哮喘患者凝血功能与不足1年患者相比，病程在1-9年之间的患者，各项指标均有统计学差异（P＜0.05），提示血栓前状态加重。而病程在1-9年之间的患者与不足1年患者相比PT、INT、TT减低。在非老年患者中，病程达10年以上的患者FIB增加、TT缩短有统计学意义；而老年患者FIB、TT差异无统计学意义。结论：支气管哮喘患者的病程延长与高凝状态不断加重存在相关性；各组间PT、PTA、INR比较均有统计学差异，考虑可能是肺部局部凝血功能变化导致的全身外源性凝血途径敏感性增高引起；在各非老年患者组中，凝血功能变化较为明显，病程达10年以上患者FIB增加、APTT、TT缩短等改变较为明显；而在老年患者中FIB增加、TT缩短则不明显。哮喘患者存在高凝状态并伴随病程进展进一步加重，提示应考虑给予哮喘患者适当的抗凝治疗，继而更好的控制哮喘，延缓病程进展，避免或减轻其并发症，提高患者生存质量。
[Abstract]:Objective: to compare the coagulation function of asthmatic patients with different course of disease, to understand the characteristics of coagulation function and whether there are differences in different course of asthma, and to analyze the possible causes of the change of coagulation function in asthmatic patients. To provide theoretical basis for the application of clotting related therapy in asthma. Methods: a retrospective case-control study was conducted to collect data of 222 patients, including age, sex, duration of disease and APTTTT, which were selected according to the criteria of inclusion and exclusion. According to the duration of the disease, each group was divided into three groups, and then each group was divided into the old group and the non-elderly group according to the age, and the above indexes were compared in two groups. Results: the coagulation function of asthmatic patients with a course of more than 10 years was significantly higher than that of patients with less than one year (P < 0.05). Patients with a course of 1-9 years had lower PTT TT than those with less than one year. In non-elderly patients, the increase of FIB in patients with a course of more than 10 years was statistically significant, but there was no significant difference in FIBTT between elderly patients and elderly patients. Conclusion: there is a correlation between the prolongation of the course of the disease and the exacerbation of hypercoagulability in patients with bronchial asthma. It may be that the sensitivity of systemic exogenous coagulation pathway is increased due to the changes of pulmonary local coagulation function, and the change of coagulation function is more obvious in all non-elderly patients. The increase of FIB and the shortening of APTT TT were more obvious in the patients with the course of more than 10 years, but not in the elderly patients. The hypercoagulable state of asthmatic patients and the further aggravation of the course of the disease suggest that appropriate anticoagulant therapy should be taken into account in order to better control the asthma, delay the progression of the disease, and avoid or reduce the complications. Improve the quality of life of patients.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R562.25

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