血清和肽素、降钙素原在慢性阻塞性肺疾病急性加重患者中的临床价值

发布时间：2018-05-28 09:44

本文选题：慢性阻塞性肺疾病急性加重 + 和肽素　；参考：《宁夏医科大学》2015年硕士论文

【摘要】：目的:分析血清和肽素、降钙素原对慢性阻塞性肺疾病急性加重(AECOPD)患者的临床意义。方法:对收治入院的150例AECOPD患者进行治疗前后血清和肽素(CPP)、降钙素原(PCT)、C反应蛋白(CRP)的检测,并分析CPP、PCT与慢性阻塞性肺疾病严重程度的关系及慢性阻塞性肺疾病生活质量评分表(CAT评分),6分钟步行距离(6 MWD)的相关性。结果:1.AECOPD治疗前血清CPP、PCT、CRP显著高于治疗后和正常对照组(t=4.798,Z=-6.356,Z=-7.492,P值均P0.01),AECOPD治疗后患者的血清CPP、PCT、CRP均高于正常对照组(t=4.809,Z=-5.415,Z=-4.495,P值均0.01);2.血清CPP、CRP在稳定期COPD不同肺功能分级有统计学意义(P值均0.05);且血清CPP水平在一定程度上随着病情严重程度的增加而增加;3.CPP水平与患者生活质量评估表(CAT)呈正相关性(r=0.336,P=0.000);与运动能力评估指标6分钟步行距离(6 WMD)呈负相关性(r=-0.350,P=0.000)。结论:血清CPP和PCT可评估慢性阻塞性肺疾病急性加重及其治疗疗效;血清CPP水平在一定程度上可以反映AECOPD患者病情严重程度,对患者的生活质量评估具有一定的临床价值。
[Abstract]:Objective: to analyze the clinical significance of serum peptide and procalcitonin in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: before and after treatment, the serum and peptide levels of 150 patients with AECOPD and procalcitonin C reactive protein (CRP) were detected. The relationship between CPPnPCT and the severity of chronic obstructive pulmonary disease (COPD) and the correlation between cat score and 6-minute walking distance (6MWD) were analyzed. Results 1. Before and after AECOPD treatment, the CRP of serum CPPmP was significantly higher than that after treatment and normal control group (P < 0.01). The levels of serum CPPnPCTnr were significantly higher than those of the normal control group (P = 4.809Z-5.415Z-4.495P, P = 0.02P, respectively) after AECOPD treatment, and the level of CRP was significantly higher than that of the normal control group (P < 0.01) after AECOPD treatment. The levels of CRP in the patients with AECOPD were significantly higher than those in the control group (t 4.809Z -5.415Z -4.495P). The level of serum CPP was significantly higher than that of the control group (P < 0.05), and the level of serum CPP increased with the severity of the disease to a certain extent, and there was a positive correlation between the level of serum CPP and the quality of life assessment (QOL) of the patients. There was a negative correlation between 0.336m ~ (0.000) and 6-minute walking distance (6W MDM), a negative correlation between 0.350m ~ (0.350) ~ 0.000 ~ (-1) ~ 0.000 ~ 0.000 ~ 0.000 ~ (-1) ~ (-1) and 6 minutes walking distance (n = 6). Conclusion: serum CPP and PCT can evaluate the acute exacerbation of chronic obstructive pulmonary disease and its therapeutic effect, and the serum CPP level can reflect the severity of AECOPD to a certain extent, and has certain clinical value to evaluate the quality of life of patients with chronic obstructive pulmonary disease.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R563.9

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