沙美特罗替卡松口腔吸入治疗COPD合并肺动脉高压临床观察

发布时间：2018-05-29 11:40

本文选题：慢性阻塞性肺疾病 + 肺动脉高压　；参考：《山东医药》2017年21期

【摘要】：目的观察沙美特罗替卡松口腔吸入治疗慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)的临床效果。方法选取COPD合并PH患者64例,随机分为观察组及对照组各32例。对照组给予化痰、止咳、吸氧、抗感染等常规治疗,观察组在常规治疗基础上给予沙美特罗替卡松粉剂(沙美特罗:丙酸氟替卡松为50μg:500μg)口腔吸入,1吸/次,2次/d。两组均治疗6个月。对比两组疗效,治疗前后肺通气功能、平均肺动脉压(m PAP),血清低氧诱导因子1α(HIF-1α)、Apelin水平、生活质量评分。结果观察组总有效率(90.6%)与对照组(62.5%)比较,P0.05。治疗后观察组第1秒用力呼气容积、用力肺活量、第1秒用力呼气容积占预计值百分比、m PAP、血清HIF-1α水平、血清Apelin水平、生活质量评分与对照组比较,P均0.05。结论沙美特罗替卡松口腔吸入治疗COPD合并PH疗效佳,可有效改善患者肺功能,降低m PAP,改善其生活质量。
[Abstract]:Objective to observe the clinical effect of salmeterol fluticasone inhalation in the treatment of chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH). Methods 64 cases of COPD complicated with PH were randomly divided into two groups: observation group (n = 32) and control group (n = 32). The control group was given routine therapy such as phlegm reduction, cough relief, oxygen inhalation, anti-infection and so on. The observation group was given salmeterol: fluticasone propionate 50 渭 g / 500 渭 g oral inhaled oral cavity for 1 / 2 / d on the basis of routine treatment. The control group received oral inhalation of salmeterol: fluticasone propionate (50 渭 g / 500 渭 g). Both groups were treated for 6 months. The therapeutic effect, pulmonary ventilation function, mean pulmonary artery pressure (PAP), serum level of hypoxia inducible factor-1 伪 (HIF-1 伪) and quality of life (QOL) were compared between the two groups. Results the total effective rate of the observation group was 90.6%, compared with that of the control group (62.5%). After treatment, forced expiratory volume, forced vital capacity, forced expiratory volume in the first second and the percentage of forced expiratory volume to predicted value in the observation group were 0. 05%, serum HIF-1 伪 level, serum Apelin level, quality of life score were 0. 05% compared with the control group (P < 0. 05). Conclusion salmeterol fluticasone inhalation is effective in the treatment of COPD with PH, which can effectively improve pulmonary function, decrease Mapp and improve the quality of life.
【作者单位】：连云港市第一人民医院;
【分类号】：R544.1;R563.9

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