慢性阻塞性肺疾病患者诱导痰中正五聚蛋白3水平的变化及意义

发布时间：2018-05-30 04:09

本文选题：正五聚蛋白 + 肺疾病　；参考：《中国老年学杂志》2014年24期

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)患者诱导痰中正五聚蛋白3(PTX3)水平及其与气道炎性细胞和气道狭窄程度的关系。方法收集45例COPD急性加重期患者(A组),45例COPD稳定期患者(B组),45例健康体检者(C组),采用酶连免疫吸附分析(ELISA)法检测诱导痰中PTX3水平,并计算诱导痰中中性粒细胞数量和百分比,测定三组人群的肺功能。结果诱导痰中PTX3水平(A组B组C组)(P0.05);A组诱导痰中PTX3水平与中性粒细胞百分比呈正相关(r=0.67,P0.05),与肺功能(FEV1%pre)呈负相关(r=-0.78,P0.05);B组诱导痰中PTX3水平与肺功能(FEV1%pre)呈负相关(r=-0.57,P0.05)。结论 PTX3作为固有免疫反应的体液因子参与COPD气道炎性过程,其有望成为一种新的气道炎性标记物。
[Abstract]:Objective to investigate the relationship between the level of positive five polyprotein 3 (PTX3) in induced sputum in patients with chronic obstructive pulmonary disease (COPD) and the relationship with the degree of airway inflammatory cells and airway stenosis. Methods 45 patients with acute exacerbation of COPD (group A), 45 patients with COPD stable period (Group B) and 45 healthy subjects (group C) were detected by enzyme linked immunosorbent assay (ELISA). The level of PTX3 in sputum was induced and the number and percentage of neutrophils in the induced sputum were calculated and the lung function of the three groups was measured. The results were PTX3 level in the sputum (group B C in group A) (P0.05). The level of PTX3 in the induced sputum in the A group was positively correlated with the percentage of neutrophils (r=0.67, P0.05), and was negatively correlated with the lung function (FEV1%pre). The level of PTX3 in phlegm is negatively correlated with lung function (FEV1%pre) (r=-0.57, P0.05). Conclusion PTX3 is involved in the inflammatory process of COPD airway as the humoral factor of the inherent immune response, and it is expected to be a new airway inflammatory marker.
【作者单位】：山东大学第二医院呼吸内科;
【基金】：山东省科技发展计划(2011GSF11813)
【分类号】：R563.9

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