慢性阻塞性肺疾病患者血D-二聚体及胆红素检测的临床意义

发布时间：2018-06-01 08:26

本文选题：慢性阻塞性肺疾病 + D-二聚体　；参考：《南京医科大学学报(自然科学版)》2014年12期

【摘要】：目的 :探讨慢性阻塞性肺疾病(COPD)患者血D-二聚体(D-D)及胆红素检测的临床意义。方法 :选取COPD急性加重期患者79例、缓解期患者88例及76例健康体检者为对照组,检测血D-D及胆红素水平,分析D-D水平与胆红素的相关性。结果:COPD缓解期及急性加重期患者D-D水平均高于正常对照组,总胆红素(TBIL)、直接胆红素(DBIL)及间接胆红素(IBIL)水平均低于正常对照组(P0.05或P0.01);COPD急性加重期患者D-D水平高于缓解期患者,TBIL、DBIL及IBIL水平则低于缓解期患者(P0.05或P0.01)。COPD患者D-D水平与TBIL(r=-0.474,P0.01)及IBIL(r=-0.365,P0.05)呈负相关。结论:血D-D水平增高及胆红素水平降低与COPD的急性加重有关,动态监测D-D及胆红素水平变化对判断COPD病情发展有一定指导意义。
[Abstract]:Objective: to investigate the clinical significance of serum D-dimer D-D) and bilirubin in patients with chronic obstructive pulmonary disease (COPD). Methods: the serum D-D and bilirubin levels were measured in 79 patients with acute exacerbation of COPD, 88 patients with remission and 76 healthy controls. The correlation between D-D and bilirubin was analyzed. Results the levels of D-D in patients with 0: COPD in remission and acute exacerbation were higher than those in normal controls. The levels of total bilirubin TBILL, direct bilirubin (DBIL) and indirect bilirubin (IBIL) were lower than those of normal control group (P 0.05 or P 0.01). The levels of D-D in patients with acute exacerbation of COPD were higher than those in patients with acute exacerbation of COPD in remission stage, while the levels of DBIL and IBIL in patients with COPD were lower than those in patients with remission or P0.01).COPD. There was a negative correlation between TBILR- 0.474 (P0.01) and IBILR- 0.365 (P0.05). Conclusion: the increase of blood D-D level and the decrease of bilirubin level are related to the acute exacerbation of COPD. Dynamic monitoring of D-D and bilirubin levels is helpful to judge the development of COPD.
【作者单位】：东南大学医学院附属盐城医院检验科;
【分类号】：R563.9

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