老年慢性阻塞性肺疾病患者肺部真菌感染的临床分析

发布时间：2018-06-02 00:19

本文选题：老年 + 慢性阻塞性肺疾病　；参考：《中华医院感染学杂志》2014年03期

【摘要】：目的探讨老年慢性阻塞性肺疾病(COPD)患者肺部真菌感染的临床特点,分析真菌分布及感染危险因素,以指导临床治疗与预防。方法回顾性分析2008年1月-2013年10月649例老年COPD患者的临床资料,对患者的痰液进行真菌培养,记录其在住院期间是否并发肺部真菌感染,分析真菌的分布,并采用SPSS19.0软件对数据进行统计分析。结果 649例COPD患者中并发肺部真菌感染34例,感染率为5.24%;34例感染患者共培养出真菌34株,其中以白色假丝酵母菌为主20株,占58.9%,其次为热带假丝酵母菌5株、曲霉菌属4株,分别占14.7%、11.8%;患者高龄、糖尿病、糖皮质激素及抗菌药物的使用、侵入性操作等原因是老年COPD患者肺部真菌感染的主要危险因素。结论肺部真菌感染是老年COPD患者严重的并发症,减少或避免可能导致真菌感染的各种因素,早期诊断及治疗可减少肺部感染的概率、降低患者的病死率。
[Abstract]:Objective to investigate the clinical characteristics of pulmonary fungal infection in elderly patients with chronic obstructive pulmonary disease (COPD) and to analyze the distribution of fungi and the risk factors of infection in order to guide the clinical treatment and prevention. Methods the clinical data of 649 elderly patients with COPD from January 2008 to October 2013 were retrospectively analyzed. The sputum of the patients were cultured to record whether they were complicated with pulmonary fungal infection during hospitalization and the distribution of fungi was analyzed. The data are analyzed by SPSS19.0 software. Results among the 649 patients with COPD, 34 cases were complicated with pulmonary fungal infection, and the infection rate was 5.24%. Among them, 20 strains were Candida albicans, 58.9% were Candida albicans, 5 strains were Candida tropicalis and 4 strains were Aspergillus. The main risk factors of pulmonary fungal infection in elderly patients with COPD were elderly patients, diabetes mellitus, use of glucocorticoid and antimicrobial agents, invasive operation and so on. Conclusion Pulmonary fungal infection is a serious complication in elderly patients with COPD. Early diagnosis and treatment can reduce the probability of pulmonary infection and reduce the mortality of patients.
【作者单位】：金华市武义县第一人民医院呼吸科;
【基金】：浙江省科技厅基金资助项目(2009F80683)
【分类号】：R563.9

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