整合素和金属蛋白酶域33基因V4多态性与支气管哮喘易患性关系的Meta分析

发布时间：2018-06-05 23:08

本文选题：哮喘 + 多态性　；参考：《中国全科医学》2014年21期

【摘要】：目的探讨整合素和金属蛋白酶域33(ADAM33)基因V4(rs2787094 GC)多态性与支气管哮喘易患性的关系。方法检索中国生物医学文献数据库(CBM)、维普网、万方数据知识服务平台、中国知网(CNKI)、PubMed、EMBase、Google学术、Web of Science等电子数据库,检索范围均从建库至2013年8月,筛选符合纳入标准的文献,由两位研究员进行数据收集、提取。采用Stata 12.0软件进行Meta分析。结果最终共纳入8篇文献,均为病例对照研究,共包括2 128例支气管哮喘患者(病例组)和3 134例健康对照者(对照组)。Meta分析结果显示:在等位基因模型和显性模型中,ADAM33基因V4多态性与支气管哮喘易患性有关〔G与C:OR=1.58,95%CI(1.14,2.18),P=0.006;GG+GC与CC:OR=1.42,95%CI(1.25,1.60),P=0.000〕。亚组分析结果显示:对照组来源为普通人群时,在等位基因模型和显性模型中,ADAM33基因V4多态性与支气管哮喘易患性有关〔G与C:OR=1.58,95%CI(1.06,2.35),P=0.024;GG+GC与CC:OR=1.40,95%CI(1.22,1.60),P=0.000〕;对照组来源为医院人群时,在等位基因模型中,ADAM33基因V4多态性与支气管哮喘易患性无关〔OR=1.57,95%CI(0.73,3.37),P=0.244〕,在显性模型中,ADAM33基因V4多态性与支气管哮喘易患性有关〔OR=1.53,95%CI(1.12,2.08),P=0.000〕。采用聚合酶链反应-限制性片段长度多态性检测法(PCR-RFLP)进行检测时,在等位基因模型和显性模型中,ADAM33基因V4多态性与支气管哮喘易患性有关〔G与C:OR=2.21,95%CI(1.44,3.40),P=0.001;GG+GC与CC:OR=2.29,95%CI(1.88,2.78),P=0.000〕;采用其他检测方法时,在等位基因模型和显性模型中,ADAM33基因V4多态性与支气管哮喘易患性无关〔G与C:OR=1.07,95%CI(0.94,1.21),P=0.314;GG+GC与CC:OR=1.02,95%CI(0.87,1.20),P=0.769〕。结论 ADAM33基因V4多态性可能与支气管哮喘易患性增加有关,有可能作为早期诊断支气管哮喘的分子标志物。
[Abstract]:Objective to investigate the relationship between the polymorphism of integrin and metalloproteinase domain 33 (ADAM33) gene V4 rs2787094 GC and the susceptibility to bronchial asthma. Methods Chinese biomedical literature databases, such as CBMU, Weipu Web, Wanfang data knowledge Service platform, CNKI / PubMed.com, Google academic Web of Science and other electronic databases, were retrieved from the establishment of the database to August 2013, and the documents that met the inclusion criteria were selected. Data were collected and extracted by two researchers. Stata 12.0 software was used for meta analysis. Results A total of 8 articles were included, all of which were case-control studies. A total of 2 128 patients with bronchial asthma (case group) and 3 134 healthy controls (control group). Meta-analysis showed that the V4 polymorphism of the ADAM33 gene was associated with the susceptibility to asthma in allelic and dominant models. G and C: OR1. 58 and 95; CI1. 14 / 2.18; P0. 006; GG; CC: OR1. 42 / 95; CIQ: 1. 25; 1. 60; P0. 000. The results of subgroup analysis showed that the V4 polymorphism of ADAM33 gene was associated with the susceptibility to bronchial asthma in allelic and dominant models when the control group was from the general population. In allelic model, the V4 polymorphism of ADAM33 gene was not associated with the susceptibility to bronchial asthma. In the dominant model, the V4 polymorphism of the ADAM33 gene was associated with the susceptibility of bronchial asthma, and there was no correlation between the V4 polymorphism and the susceptibility to bronchial asthma, and there was no correlation between the V4 polymorphism of the ADAM33 gene and the susceptibility to bronchial asthma, and the relationship between the V4 polymorphism of the ADAM33 gene and the susceptibility to bronchial asthma was not related to the susceptibility to bronchial asthma, and the relationship between the V4 polymorphism of ADAM33 gene and the susceptibility to bronchial asthma was found. In allelic and dominant models, the V4 polymorphism of ADAM33 gene was associated with the susceptibility to bronchial asthma by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Using other detection methods, the V4 polymorphism of ADAM33 gene was not related to the susceptibility to bronchial asthma in allelic and dominant models. Conclusion the V4 polymorphism of ADAM33 gene may be associated with increased susceptibility to bronchial asthma and may be used as a molecular marker for early diagnosis of bronchial asthma.
【作者单位】：大连医科大学附属第一医院呼吸内科;大连大学附属中山医院;大连医科大学附属第一医院消化内科;
【分类号】：R562.25

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