不同类型特发性间质性肺炎患者胶原与血管生成相关因子的表达差异

发布时间：2018-06-06 12:40

  本文选题：特发性肺纤维化 + 非特异性间质性肺炎　； 参考：《实用医学杂志》2017年05期

【摘要】：目的:分析不同类型特发性间质性肺炎(IIP)患者胶原与血管生成相关因子的表达差异。方法:收集2003年1月至2014年11月间,北京朝阳医院呼吸与危重症医学科住院确诊的187例IIP患者,分为特发性肺纤维化118例(IPF组),除IPF外的其他类型IIP 69例(nIPF-IIP组)两个亚组,其中nIPF-IIP组包括NSIP 30例,COP 29例;RB-ILD 10例。对照组68例,为男38例,女30例。收集患者及对照组支气管肺泡灌洗液(BALF)和血清,应用酶联免疫吸附法(ELISA)分别检测BALF及血清中I型前胶原(PCI)、Ⅲ型前胶原(PCⅢ)、人上皮细胞衍生中性粒细胞激活肽-78(ENA-78)和人γ干扰素诱导的蛋白-10(IP-10)的含量,对所测指标进行组间比较。结果:IPF患者组及nIPF-IIP组的BALF和血清中PCⅢ含量(ng/mL)均显著高于对照组[BALF:4.65±0.06,2.90±0.40 vs.1.31±0.16,均P0.05;血清:11.49±0.98,3.37±0.16vs.1.98±0.09,均P0.05)在IPF患者组升高尤为明显。而3组间BALF和血清中PC I含量差异均无统计学意义(均P0.05)。BALF中ENA-78含量(ng/mL)在IPF组和nIPF-IIP组均较正常对照组升高(17.85±0.44,18.89±0.45 vs.14.86±0.63,均P0.05;),但在二组之间无明显差异(P=0.139)。而BALF中IP-10含量(ng/mL)在IPF组和nIPF-IIP组均较对照组降低(0.25±0.01,0.21±0.01 vs.0.35±0.03,均P0.05),且在nIPF-IIP患者的降低幅度较IPF患者大(P=0.040)。BALF中ENA-78含量与IP-10含量负相关(r=-0.378,P=0.02)。而血清ENA-78及IP-10变化不明显。结论:IPF患者较nIPF-IIP患者存在更明显的胶原代谢异常;IPF和nIPF-IIP患者肺脏的血管生成活性均增加。
[Abstract]:Aim: to analyze the expression of collagen and angiogenic factors in patients with different types of idiopathic interstitial pneumonia (IIP). Methods: from January 2003 to November 2014, 187 IIP patients who were admitted to the Department of Respiratory and critical Care Medicine, Chaoyang Hospital, Beijing, were divided into two subgroups: 118 patients with idiopathic pulmonary fibrosis (IPF) and 69 patients with IIP other than IPF (n = 69). The nIPF-IIP group included 30 cases of NSIP and 29 cases of RB-ILD. There were 68 cases in the control group, 38 males and 30 females. Bronchoalveolar lavage fluid (BALF) and serum were collected from patients and control group. The levels of BALF, type 鈪，

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