噻托溴铵联合氨茶碱对老年慢性阻塞性肺病患者肺功能和炎症因子水平的影响

发布时间：2018-06-06 14:08

本文选题：噻托溴铵 + 氨茶碱　；参考：《中国老年学杂志》2017年18期

【摘要】：目的探讨噻托溴铵联合氨茶碱对老年慢性阻塞性肺病(COPD)患者肺功能和炎症因子水平的影响。方法 120例COPD患者按照随机数字表法分为对照组和治疗组各60例;对照组单用氨茶碱治疗,治疗组联用氨茶碱与噻托溴铵治疗,分别在治疗前、治疗后4、12 w抽血检测血清白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α含量;用肺功能测试仪测试最大呼气流量(PEF)、用力肺活量(FVC)及第1秒用力呼气量占预计值百分比(FEV1%);用中文版英国医学研究委员会呼吸困难分级评分评估呼吸困难程度;用中文版世界卫生组织生存质量测定量表简表(WHOQOLBREF)评价生活质量。结果治疗后两组均逐渐改善,治疗组治疗4 w后FVC明显高于对照组,12 w后FEV1、FVC、FEV1%均明显高于对照组(均P0.05);治疗组4 w后TNF-α含量明显低于对照组,12 w后IL-8、TNF-α含量均明显低于对照组(均P0.05);治疗组治疗12 w后呼吸困难程度明显轻于对照组,WHOQOL-BREF评分明显高于对照组(均P0.05)。结论老年COPD患者采用噻托溴铵联合氨茶碱治疗,疗效确切,安全性高,可有效缓解炎症反应,提高肺功能,改善生活质量。
[Abstract]:Objective to investigate the effects of tiotropium bromide combined with aminophylline on pulmonary function and inflammatory factors in elderly patients with chronic obstructive pulmonary disease (COPD). Methods one hundred and twenty patients with COPD were randomly divided into control group (n = 60) and treatment group (n = 60), the control group was treated with aminophylline alone, the treatment group was treated with aminophylline and tiotropium bromide, and the control group was treated with aminophylline and tiotropium respectively. The levels of IL-8 and TNF- 伪 in serum were measured at 4 weeks and 12 weeks after treatment. The maximal expiratory flow (PEFV), forced vital capacity (FVCC) and the percentage of forced expiratory volume (FV1) in the predicted value were measured with the pulmonary function tester, and the degree of dyspnea was assessed by the Chinese version of the British Medical Research Council (BRC) rating score of dyspnea. The quality of life (QOL) was evaluated by World Health Organization (WHO) quality of Life scale (WHOQOLBREF). Results after treatment, the two groups improved gradually. FVC in the treatment group was significantly higher than that in the control group after 12 weeks of treatment (all P 0.05), and the level of IL-8 TNF- 伪 in the treatment group was significantly lower than that in the control group after 12 weeks of treatment (all P 0.05). The score of WHOQOL-BREF in the control group was significantly lower than that in the control group (P < 0.05). Conclusion tiotropium bromide combined with aminophylline is effective and safe in elderly patients with COPD. It can effectively relieve inflammation, improve lung function and improve quality of life.
【作者单位】：遵义市妇幼保健院内科;
【分类号】：R563.9

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