吸气分数度与稳定期中重度COPD患者运动耐力相关性研究

发布时间：2018-06-07 04:41

  本文选题：运动耐力 + 稳定期　； 参考：《中国实用内科杂志》2014年S1期

【摘要】：目的探讨深吸气量(IC)、深吸气量与肺总量之比(IC/TLC)(或称吸气分数,IF)及相关肺功能指标与稳定期中重度COPD患者运动耐力的相关性。方法对42例处于稳定期的中重度COPD患者及34例同年龄段健康志愿者进行常规肺功能检测(PFT)及斜坡式功率递增症状限制性心肺运动试验(CPET),测定相关肺通气功能参数、气体交换参数,并记录受试者CPET的终止原因。结果 (1)COPD患者的IF与运动耐力(峰值摄氧量占预计值的百分比,peak VO2%pred)有显著的相关性(r=0.74,p0.001),IF可作为预估COPD患者运动耐力减低的独立变量,并且其敏感度及特异度均高于FEV1%pre,多重线性回归模型方程为:peak VO2%pred=94.85IF+0.4FEV1%pred+29.2(RC2=0.61,P0.001),(2)低IF值(0.23)的COPD患者(13例)比高IF值(≥0.23)COPD患者(29例)有着更严重的肺过度充气(IC%pred为(51.25±9.46)%对(79.38±17.22)%;P0.05)及运动耐力下降[peak VO2%pred为(56.0±6.23)%对(84.52±10.05)%,P0.01),(3)低IF值(0.23)与高IF值(≥0.23)的COPD患者在峰值运动时的呼吸频率[peakBF为(31.62±7.1)对(32.21±6.3)breaths/min,P0.05],无显著性差异的情况下,前者的峰值分钟通气量(peak VE)及峰值潮气量(peak VT)均较后者下降[(35.62±8.10)对(49.14±12.59)L/min,(1.11±0.25)对(1.57±0.35)L,P0.05];低IF值(0.23)的COPD患者中有11例(84.6%)因呼吸困难终止运动,高IF值(≥0.23)COPD患者中有12例(41.4%)因呼吸困难终止运动,13例(44.8%)因腿酸乏力停止运动,两组间终止运动原因的构成比差异具有统计学意义(P0.05)。结论吸气分数较FEV1可更好的反映肺过度充气及预估稳定期中重度COPD患者的运动耐力。
[Abstract]:Objective to investigate the correlation between the ratio of deep inspiratory volume and total lung volume and the relative pulmonary function and exercise endurance in patients with moderate and severe COPD at stable stage. Methods 42 moderate and severe COPD patients at stable stage and 34 healthy volunteers of the same age were examined by routine pulmonary function test (PFTs) and slope power increase symptom restricted cardiopulmonary exercise test (CPETT), and the relevant pulmonary ventilation parameters were measured. Gas exchange parameters were recorded and the cause of termination of CPET was recorded. Results there was a significant correlation between if and exercise endurance (peak oxygen uptake as a percentage of predicted value) in patients with COPD. And its sensitivity and specificity are higher than FEV1pre. the multiple linear regression equation is: 1 / peak VO2%pred=94.85IF 0.4FEV1%pred 29.2n / RC2n 0.61C _ (0.61p _ (0.001) P _ (0.23) there are more severe lung hyperinflatable ICpred (51.25 卤9.46% vs 79.38 卤17.22P 0.05) and higher if value (鈮，

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