血清PCT与Hs2CRP和SAA水平在老年慢性阻塞性肺疾病急性加重期下呼吸道感染诊断中的临床意义

发布时间：2018-06-08 04:19

  本文选题：慢性阻塞性肺疾病 + 下呼吸道感染　； 参考：《中华医院感染学杂志》2016年17期

【摘要】：目的研究分析血清降钙素原(PCT)、超敏C-反应蛋白(Hs2CRP)和血清淀粉样蛋白A(SAA)水平在老年慢性阻塞性肺疾病急性加重期下呼吸道感染诊断中变化的临床意义。方法随机选取2013年10月-2015年10月临床治疗治的95例老年慢性阻塞性肺疾病患者为研究对象,呼吸道细菌感染患者48例设为观察组,余47例为对照组;对两组患者的血清PCT、Hs2CRP和SAA水平进行检测,分析两组患者指标变化的临床意义。结果观察组患者血清PCT(3.35±0.03)ng/ml、Hs2CRP(64.75±19.03)mg/L和SAA(85.47±13.52)mg/L水平显著高于对照组(P0.05),观察组患者治疗后的血清PCT、Hs2CRP和SAA水平分别为(0.28±0.04)ng/ml、(14.35±3.06)mg/L、(12.86±2.95)mg/L,较治疗前均显著改善(P0.05);同时PCT、Hs2CRP及SAA水平检测也表现出较高的特异性和灵敏性。结论老年慢性阻塞性肺疾病急性加重期下呼吸道感染采用血清PCT、Hs2CRP及SAA水平检测对临床诊断和治疗具有积极的意义。
[Abstract]:Objective to study the clinical significance of serum calcitonin proto-PCTX, hypersensitive C-reactive protein (Hs2CRP) and serum amyloid protein (Alosa) in the diagnosis of lower respiratory tract infection (LRTI) in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Ninety-five elderly patients with chronic obstructive pulmonary disease were randomly selected from October 2013 to October 2015. 48 patients with respiratory tract bacterial infection were selected as observation group and 47 patients as control group. The serum levels of PCTs2 CRP and SAA were measured in two groups, and the clinical significance of the changes in the two groups was analyzed. Results the levels of serum PCTHs2CRPN in the observation group (3.35 卤0.03ng / ml) were significantly higher than those in the control group (64.75 卤19.03 mg / L and 85.47 卤13.52 mg / L, respectively). The serum levels of PCTHs2CRP and SAA in the observation group were 0.28 卤0.04 ng / ml, 14.35 卤3.06 mg / L, 12.86 卤2.95 mg / L, respectively, which were significantly improved compared with those before treatment, and the detection of PCTHs2CRP and SAA also showed high specificity and sensitivity. Conclusion the detection of serum PCTV-Hs2CRP and SAA levels in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) is of positive significance for clinical diagnosis and treatment.
【作者单位】： 山东省兰陵县人民医院呼吸科;
【基金】：山东省卫生厅基金资助项目(SW-2010-028)
【分类号】：R563.9
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本文编号：1994425