在治疗急性肺血栓栓塞过程中对心肌细胞缺血缺氧保护的实验研究

发布时间：2018-06-15 01:09

本文选题：PTE + cTn　；参考：《大理学院》2013年硕士论文

【摘要】：目的:研究左卡尼汀在治疗急性肺血栓栓塞过程中对心肌细胞缺血缺氧的治疗和保护的作用. 方法:通过造模,造成SD大鼠急性肺血栓栓塞,并进行溶栓,在常规溶栓过程中，，加用左卡尼汀,观察该药物在治疗急性肺血栓栓塞过程中对心肌细胞所起的作用. 结果:急性肺血栓栓塞(PTE)为急性发病,且致死率极高, PTE患者会不同程度的伴发心肌细胞的缺血缺氧,类似急性心肌梗死,溶栓可恢复受损的肺组织细胞,但心肌细胞的恢复却效果很差,本实验中,溶栓过程中加入左卡尼汀,既恢复受损的肺组织,而且使心肌细胞缺血缺氧的状态得到了缓解.很大程度上促进了溶栓治疗的效果. 结论：急性肺血栓栓塞,伴发心肌细胞的缺血缺氧,同时出现类似急性心肌梗死的心电图表现和cTn改变,溶栓同时加用左卡尼汀,溶栓结束后,测量cTn,其明显比单用溶栓药有所降低.因此,可以证明左卡尼汀在治疗急性肺血栓栓塞过程中有重要临床意义.
[Abstract]:Aim: to study the protective effect of levacarnitine on myocardial ischemia and hypoxia in the treatment of acute pulmonary thromboembolism. Methods: acute pulmonary thromboembolism was induced and thrombolytic therapy was carried out in SD rats. In the course of routine thrombolytic therapy, levacarnitine was added to observe the effect of the drug on cardiomyocytes during the treatment of acute pulmonary thromboembolism. Results: acute pulmonary thromboembolism (PTE) is an acute disease with high mortality. Pte patients may be accompanied by myocardial ischemia and hypoxia in varying degrees, similar to acute myocardial infarction. Thrombolytic therapy can restore damaged lung tissue cells. However, the effect of cardiomyocyte recovery was very poor. In this experiment, levocarnitine was added to the thrombolytic process, which not only recovered the damaged lung tissue, but also alleviated the ischemia and hypoxia of myocardial cells. To a large extent, the effect of thrombolytic therapy was promoted. Conclusion: acute pulmonary thromboembolism, accompanied by ischemia and hypoxia of cardiac myocytes, accompanied by changes of ECG and cTn similar to acute myocardial infarction, thrombolytic therapy combined with L-carnitine, after thrombolytic therapy, The measurement of cTnwas significantly lower than that of single thrombolytic agent. Therefore, it can be proved that levacarnitine has important clinical significance in the treatment of acute pulmonary thromboembolism.
【学位授予单位】：大理学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.5

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