血清HIF-1α水平在慢性阻塞性肺疾病急性加重期的预后预测价值

发布时间：2018-06-16 23:26

本文选题：慢性阻塞性肺疾病 + 低氧诱导因子-α　；参考：《广东医学》2017年09期

【摘要】：目的探讨血清缺氧诱导因子-1α(HIF-1α)对慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的预测价值。方法 AECOPD患者100例,检测患者入院时血清HIF-1α、血白细胞计数、C反应蛋白(CRP)水平,并在其出院后半年、1年分别电话随访,记录患者住院时间、1年内再次住院率及病死率,研究HIF-1α与以上各项指标的相关性。结果 100例AECOPD患者中,男67例,女33例,平均年龄(64.4±5.6)岁,高HIF-1α组白细胞计数、CRP水平显著高于低HIF-1α组,差异有统计学意义(P0.001);高HIF-1α组的住院时间较低HIF-1α组延长,1年内住院率及病死率增高,两组差异有统计学意义(P0.001)。结论血清HIF-1α水平能够预测AECOPD患者生存率及其再次入院的风险,这在临床上对于AECOPD患者的诊治有重要的帮助作用。
[Abstract]:Objective to investigate the prognostic value of serum hypoxia inducible factor-1 伪 (HIF-1 伪) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 100 patients with AECOPD were enrolled in the study. The serum HIF-1 伪, leukocyte count and C-reactive protein (CRP) were measured at admission. The patients were followed up by telephone for six months and one year after discharge. The hospitalization time, the re-hospitalization rate and the fatality rate within one year were recorded. To study the correlation between HIF-1 伪 and the above indexes. Results among the 100 AECOPD patients, 67 were male and 33 female, with an average age of 64.4 卤5.6 years. The level of CRP in high HIF-1 伪 group was significantly higher than that in low HIF-1 伪 group. The hospitalization time of the high HIF-1 伪 group was longer than that of the lower HIF-1 伪 group, and the hospitalization rate and mortality increased within one year. The difference between the two groups was statistically significant (P 0.001). Conclusion Serum HIF-1 伪 level can predict the survival rate and the risk of readmission in AECOPD patients, which is helpful to the diagnosis and treatment of AECOPD patients.
【作者单位】：潮州市人民医院重症医学科;潮州市人民医院急诊科;潮州市人民医院风湿免疫科;
【分类号】：R563.9

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