咳嗽变异性哮喘和典型支气管哮喘患者DCs、mDC、pDC比例和数量的变化及意义

发布时间：2018-06-19 14:27

本文选题：典型支气管哮喘 + 咳嗽变异性哮喘　；参考：《广东医学》2017年03期

【摘要】：目的探讨咳嗽变异性哮喘、典型支气管哮喘患者外周血中树突状细胞(DCs)及其亚型髓样树突状细胞(m DC)、浆细胞样树突状细胞(p DC)比例和数量的变化,了解咳嗽变异性哮喘与典型支气管哮喘之间是否有类似的免疫学发病机制。方法选取典型支气管哮喘患者34例,咳嗽变异性哮喘患者17例,健康对照组17例,使用流式细胞术检测和计算典型支气管哮喘与咳嗽变异性哮喘患者外周血中DCs及其两个亚群:p DC和m DC所占比例和数量的变化。结果咳嗽变异性哮喘与典型支气管哮喘相比,其外周血DCs及其亚型的数量和比例均差异无统计学意义(P0.05),咳嗽变异性哮喘、典型支气管哮喘与健康对照组比较,p DC数量及比例明显升高,m DCs/p DCs的比值降低差异有统计学意义(P0.05)。结论咳嗽变异性哮喘与支气管哮喘的发病机制在免疫学上类似,由于p DCs比例和数量的增多引起Th2细胞数量增多,造成Th1/Th2平衡向Th2细胞偏移。
[Abstract]:Objective to investigate the changes of the percentage and quantity of dendritic cells (DCs), myeloid dendritic cells (MDCs) and plasmacyte dendritic cells (MDCs) in peripheral blood of patients with cough variant asthma and typical bronchial asthma. To understand whether there is a similar immunological mechanism between cough variant asthma and typical bronchial asthma. Methods 34 cases of typical bronchial asthma, 17 cases of cough variant asthma and 17 cases of healthy control group were selected. Flow cytometry was used to detect and calculate the percentage and number of DCs and their two subgroups in peripheral blood of patients with typical asthma and cough variant asthma. Results there was no significant difference in the number and proportion of DCs and their subtypes between cough variant asthma and typical bronchial asthma. Compared with the control group, the number and proportion of DC in typical bronchial asthma group were significantly higher than those in the control group, and the ratio of DC / DC decreased significantly (P 0.05). Conclusion the pathogenesis of cough variant asthma and bronchial asthma is similar in immunology. Th2 cells increase due to the proportion and number of p-DCs, resulting in the shift of Th1 / Th2 balance to Th2 cells.
【作者单位】：南阳市中心医院呼吸内科一病区;南阳医学高等专科学校基础部;
【分类号】：R562.25

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