肺炎患者血清胆碱酯酶变化的意义与炎性指标间的关系

发布时间：2018-06-21 23:00

本文选题：肺炎 + 胆碱酯酶　；参考：《中华医院感染学杂志》2014年21期

【摘要】：目的探讨肺炎患者血清胆碱酯酶的变化及与炎性指标间的关系,以期发现新的炎性指标,并为该疾病的诊治与病情监测提供依据。方法以2009年3月-2012年3月在医院住院确诊的93例肺炎患者为肺炎组,随机抽取同期健康体检者60名为对照组,应用丁酰硫代胆碱法分别测定肺炎组和对照组患者血清胆碱酯酶水平,同时检测血常规、C-反应蛋白等炎症指标,分析血清胆碱酯酶与肺炎常规检测指标的相关性,留取痰液标本进行细菌学培养及鉴定。结果 93例肺炎患者检出病原菌以铜绿假单胞菌为主占45.31%;肺炎组与对照组比较,肺炎患者血清胆碱酯酶水平显著降低,差异有统计学意义(P0.05);而C-反应蛋白、中性粒细胞、白细胞计数明显升高(P0.05);Pearson直线相关分析显示,肺炎患者血清胆碱酯酶水平与C-反应蛋白、中性粒细胞及白细胞总数呈显著负相关(r值分别为-0.693,-0.451,-0.534,P0.05)。结论肺炎患者血清胆碱酯酶水平明显降低,其机制可能与参与炎症反应有关,在临床实践中血清胆碱酯酶可作为病情监测和治疗的生物标志物。
[Abstract]:Objective to investigate the changes of serum cholinesterase and the relationship between serum cholinesterase and inflammatory indexes in patients with pneumonia in order to find new inflammatory markers and provide evidence for the diagnosis and treatment of the disease and the monitoring of the disease. Methods from March 2009 to March 2012, 93 patients with pneumonia were selected as pneumonia group, and 60 healthy persons were randomly selected as control group. The levels of serum cholinesterase in patients with pneumonia and control group were measured by butyrylthiocholine method. Meanwhile, the inflammatory indexes such as blood routine C-reactive protein were detected, and the correlation between serum cholinesterase and routine detection of pneumonia was analyzed. The sputum samples were collected for bacteriological culture and identification. Results the pathogenic bacteria were mainly Pseudomonas aeruginosa 45.31 in 93 cases of pneumonia, the serum cholinesterase level in pneumonia group was significantly lower than that in control group (P0.05), while the C-reactive protein, neutrophil, cholinesterase level in pneumonia group were significantly lower than those in control group (P0.05). The level of serum cholinesterase in patients with pneumonia was negatively correlated with C- reactive protein, neutrophils and white blood cells (r = -0.693n- 0.451- 0.534P, respectively). Conclusion the level of serum cholinesterase in patients with pneumonia is obviously decreased, and its mechanism may be related to the inflammatory reaction. In clinical practice, serum cholinesterase can be used as a biomarker for disease monitoring and treatment.
【作者单位】：武装警察部队总医院南楼一科;武装警察部队总医院重症医学科;武装警察部队总医院检验科;武装警察部队总医院医务部;武装警察部队总医院首保临床部;
【基金】：首都临床特色应用研究基金资助项目(Z141107002514164) 武警总医院基金资助项目(WZ2012034)
【分类号】：R563.1

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