外周血T-SPOT.TB与胸腔积液ADA活性检测对结核性胸腔积液的诊断价值

发布时间：2018-06-24 00:11

本文选题：结核性胸腔积液 + 结核感染T细胞斑点试验　；参考：《山东医药》2017年37期

【摘要】：目的探讨外周血结核感染T细胞斑点试验(T-SPOT.TB)与胸腔积液腺苷脱氨酶(ADA)活性单独或联合检测对结核性胸腔积液的诊断价值。方法选取结核性胸腔积液患者110例作为结核组、非结核性胸腔积液患者60例作为非结核组。两组均于治疗前采集外周静脉血进行T-SPOT.TB,计数斑点形成细胞数;采集胸腔积液进行ADA活性检测。根据外周血T-SPOT.TB检测的斑点形成细胞数及ADA活性绘制ROC曲线,比较二者单独检测或联合检测对结核性胸腔积液的诊断效能。结果结核组外周血T-SPOT.TB阳性率、胸腔积液ADA阳性率高于非结核组(P0.05);结核组外周血T-SPOT.TB阳性率高于胸腔积液ADA阳性率(P0.05)。两组外周血T-SPOT.TB的A、B孔斑点形成细胞数及胸腔积液ADA活性比较差异有统计学意义(P0.05)。结核组外周血T-SPOT.T的ROC曲线下面积大于胸腔积液ADA活性检测(P0.05),其敏感度高于胸腔积液ADA活性检测(P0.05)。二者联合检测诊断结核性胸腔积液的敏感度高于单独检测(P均0.05)。结论外周血T-SPOT.TB与胸腔积液ADA活性联合检测对结核性胸腔积液的诊断效能高于二者单独检测。
[Abstract]:Objective to explore the diagnostic value of T cell spot test (T-SPOT.TB) and adenosine deaminase (ADA) activity of the pleural effusion (ADA) in the diagnosis of tuberculous pleural effusion. Methods 110 patients with tuberculous pleural effusion were selected as tuberculosis group and 60 cases of non tuberculous pleural effusion were used as non tuberculosis group. The two groups were treated with treatment. The peripheral venous blood was collected before T-SPOT.TB, and the number of spot forming cells was counted. The ADA activity was detected by collecting pleural effusion. The ROC curve was drawn according to the number of dot forming cells and ADA activity detected by T-SPOT.TB in peripheral blood. The diagnostic efficiency of the two cases was compared individually or jointly to the tuberculous pleural effusion. Results the peripheral blood of the tuberculosis group was T-SPOT. The positive rate of.TB, ADA positive rate of pleural effusion was higher than that of non tuberculosis group (P0.05), and the positive rate of T-SPOT.TB in peripheral blood of tuberculosis group was higher than that of ADA positive rate of pleural effusion (P0.05). The two groups of peripheral blood T-SPOT.TB A, B hole speckle forming cell number and ADA activity of pleural effusion were statistically significant (P0.05). The product was larger than the ADA activity of pleural effusion (P0.05), and its sensitivity was higher than that of ADA activity in pleural effusion (P0.05). The sensitivity of the two combined detection of tuberculous pleural effusion was higher than that of the individual (P 0.05). Conclusion the diagnostic efficacy of T-SPOT.TB in peripheral blood and ADA activity in pleural effusion was higher than that of two. Only test.
【作者单位】：九江市第三人民医院;
【基金】：江西省卫计委科技计划项目(20157107)
【分类号】：R521.7

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