低胆固醇血症对肺结核合并肺部感染的影响

发布时间：2018-07-01 07:37

本文选题：胆固醇 + 肺结核　；参考：《实用医学杂志》2017年23期

【摘要】：目的研究低胆固醇血症对肺结核合并肺部感染的影响。方法收集300例肺结核合并肺部感染患者(观察组)和300例单纯肺结核患者(对照组)的临床资料,比较两组患者年龄、性别、痰菌情况、丙氨酸氨基转氨酶(ALT)、门冬氨酸氨基转氨酶(AST)、血肌酐(Scr)、血尿素氮(BUN)、白细胞(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、血清白蛋白(ALB)、血红蛋白(HB)、血淋巴细胞总数(TLC)、血浆总胆固醇(TC)的差异,探讨低胆固醇血症对肺结核合并肺部感染的影响,分析低胆固醇血症与肺炎严重程度(CURB-65评分)的相关性。结果单因素Logistic分析提示低蛋白血症、低淋巴细胞血症、低胆固醇血症是肺结核合并肺部感染的危险因素(P0.05);多因素Logistic逐步回归分析提示低胆固醇血症是肺结核合并肺部感染的独立危险因素(P0.05);TC与CURB-65评分存在负相关;肺炎低危组(CURB-65评分为0~1分)、肺炎中危组(CURB-65评分为2分)、肺炎高危组(CURB-65评分为3~5分)TC水平差异有统计学意义(P0.01)。结论低胆固醇血症是肺结核合并肺部感染的独立危险因素,且胆固醇降低程度与肺炎严重程度相一致。
[Abstract]:Objective to study the effect of hypocholesterolemia on pulmonary tuberculosis with pulmonary infection. Methods the clinical data of 300 cases of pulmonary tuberculosis complicated with pulmonary infection (observation group) and 300 cases of simple pulmonary tuberculosis (control group) were collected, and the age, sex and sputum bacteria of the two groups were compared. Alanine aminotransferase (alt), aspartate aminotransferase (AST), serum creatinine (SCR), blood urea nitrogen (bun), leukocyte (WBC) C-reactive protein (CRP), procalcitonin (PCT), serum albumin (ALB), hemoglobin (HB), total lymphocyte count (TLC), plasma total cholesterol (TC), To investigate the effect of hypocholesterolemia on pulmonary tuberculosis with pulmonary infection, and to analyze the correlation between hypocholesterolemia and severity of pneumonia (CURB-65 score). Results univariate logistic analysis showed hypoproteinemia and hypolipidemia. Hypocholesterolemia was a risk factor for pulmonary tuberculosis complicated with pulmonary infection (P0.05), multivariate logistic stepwise regression analysis showed that hypocholesterolemia was an independent risk factor for pulmonary tuberculosis with pulmonary infection (P0.05) and TC was negatively correlated with CURB-65 score. There were significant differences in TC levels between low risk group (CURB-65 score 0 ~ 1), pneumonia middle risk group (CURB-65 score 2) and high risk pneumonia group (CURB-65 score 3 ~ 5) (P0.01). Conclusion hypocholesterolemia is an independent risk factor for pulmonary tuberculosis complicated with pulmonary infection, and the degree of cholesterol lowering is consistent with the severity of pneumonia.
【作者单位】：广州市胸科医院结核内科呼吸疾病国家重点实验室;
【基金】：广东省医学科学技术研究基金资助项目(编号:A2016113) 广州市科技计划课题(编号:155700012)
【分类号】：R521;R563.1

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