COPD患者血清MCP-1、SAA水平与认知功能的相关性研究

发布时间：2018-07-01 15:46

本文选题：慢性阻塞性肺疾病 + 蒙特利尔认知量表　；参考：《四川大学学报(医学版)》2016年06期

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)患者血清单核细胞趋化蛋白-1(MCP-1)、血清淀粉样蛋白A(SAA)水平与认知功能的关系,为临床COPD并发认知功能障碍提供新的预防和治疗思路。方法 62例COPD患者,依据血气分析将其分为缺氧组(25例)和无缺氧组(37例),同期30例健康体检人群为对照组。采用酶联免疫吸附法测定COPD患者及对照人群血清MCP-1、SAA浓度;采用蒙特利尔认知评估量表(MoCA量表)进行认知功能评分;并分析血清MCP-1、SAA水平与认知功能评分间的相关性。结果 COPD患者血浆MCP-1、SAA水平〔分别为(153.51±21.48)ng/L,(105.32±34.63)μmol/L〕高于健康对照组〔(102.70±17.11)ng/L,(44.72±48.3)μmol/L〕,差异均有统计学意义(P0.05);COPD患者缺氧组和无缺氧组MoCA评分总分及各亚项评分(无缺氧组除外视空间执行能力和延时回忆亚项评分)均较对照组低,差异均有统计学意义(P0.05),缺氧组MoCA评分均低于无缺氧组,差异均有统计学意义(P0.05)。血清SAA、MCP-1水平与MoCA总分及其亚项评分均呈负相关性(P均0.01),MCP-1与SAA呈正相关(P0.01)。结论 COPD患者存在血清MCP-1、SAA水平增高,低氧血症是COPD患者认知功能障碍形成的影响因素。
[Abstract]:Objective to investigate the relationship between serum monocyte chemoattractant protein-1 (MCP-1), serum amyloid A (SAA) level and cognitive function in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-two patients with COPD were divided into hypoxia group (25 cases) and non-hypoxia group (37 cases) according to blood gas analysis. The serum levels of MCP-1 and SAA in COPD patients and controls were measured by enzyme linked immunosorbent assay (Elisa), the cognitive function scores were assessed with the Montreal Cognitive Assessment scale (MoCA), and the correlation between the serum MCP-1A level and the cognitive function score was analyzed. Results the plasma levels of MCP-1mSAA in COPD patients (153.51 卤21.48) ng / L, (105.32 卤34.63) 渭 mol / L) were significantly higher than those in healthy controls (102.70 卤17.11) ng / L, (44.72 卤48.3) 渭 mol / L). There were significant differences between the two groups (P0.05). The total score of MoCA and the scores of each subitem in hypoxia group and non-hypoxia group were lower than those in control group. The difference was statistically significant (P0.05), the MoCA score of hypoxia group was lower than that of no hypoxia group, the difference was statistically significant (P0.05). There was a negative correlation between the level of serum SAAP-1and the total score and subitem score of MoCA (P0.01), and there was a positive correlation between MCP-1 and SAA (P0.01). Conclusion the level of serum MCP-1 and SAA is increased in COPD patients. Hypoxemia is the influencing factor of cognitive dysfunction in COPD patients.
【作者单位】：华北理工大学附属医院呼吸科;
【基金】：河北省医学科学研究重点课题计划(No.20160221)资助
【分类号】：R563.9

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