抗菌药物药物利用指数与AECOPD患者抗感染治疗效果的相关性分析

发布时间：2018-07-09 16:13

本文选题：慢性阻塞性肺疾病急性加重期 + 抗菌药物　；参考：《中国药房》2017年20期

【摘要】：目的:探讨抗菌药物的药物利用指数(DUI)与慢性阻塞性肺疾病急性加重期(AECOPD)住院患者治疗效果的相关性。方法:应用药物利用评价的研究方法,以我院2013年1月-2015年12月主要诊断为AECOPD的住院患者为研究对象。采集患者诊疗信息和处方信息,筛选出住院期间只使用1种抗菌药物的患者,并与其治疗效果及再住院指标进行关联性评价。结果:纳入本研究的AECOPD患者共2 155人次,总用药频度(DDDs)大于500的抗菌药物中,DUI最接近于1.0的抗菌药物是注射用盐酸头孢替安,DUI远大于1.0的抗菌药物是注射用头孢地嗪钠,DUI远小于1.0的抗菌药物是注射用哌拉西林钠舒巴坦钠。注射用盐酸头孢替安与注射用哌拉西林钠舒巴坦钠治疗效果比较,差异有统计学意义(P0.05),但再住院情况比较差异无统计学意义(P0.05);注射用盐酸头孢替安与注射用头孢地嗪钠的治疗效果及再住院情况比较,差异均无统计学意义(P0.05)。结论:DUI与疾病治疗效果有一定的相关性,但不能简单从DUI与1.0的远近关系判断抗菌药物在疾病的治疗中是否合理,而应综合多种混杂和偏倚因素的影响,避免误读误判。
[Abstract]:Objective: to investigate the correlation between drug utilization index (DUI) of antimicrobial agents and the efficacy of treatment in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: using the drug use evaluation method, the inpatients who were mainly diagnosed as AECOPD in our hospital from January 2013 to December 2015 were studied. The information of diagnosis and treatment and prescription were collected and the patients who used only one antimicrobial during hospitalization were selected and evaluated with the effect of treatment and the index of readmission. Results: a total of 2 155 AECOPD patients were enrolled in this study. Of the antimicrobial agents whose DDDs are greater than 500, the antimicrobial agents whose DUI is closest to 1.0 are those of ceftiamol hydrochloride for injection, and the antibiotics whose DUI is far less than 1.0 for injection. Lacillin sodium sulbactam sodium. The therapeutic effects of ceftiamol hydrochloride and piperacillin sodium sulbactam for injection were compared. The difference was statistically significant (P0.05), but there was no significant difference in re-hospitalization (P0.05); the therapeutic effect of ceftiamol hydrochloride and cefdiazine sodium for injection and re-hospitalization were not statistically significant (P0.05). Conclusion there is a certain correlation between the effect of disease treatment and the effect of the disease treatment, but we can not simply judge whether the antimicrobial drug is reasonable in the treatment of disease from the relationship between DUI and 1.0, but should synthesize the influence of many kinds of mixed and biased factors to avoid misreading and misjudgment.
【作者单位】：南方医科大学附属小榄医院药剂科;
【基金】：中山市科学事业费项目(医疗卫生)(No.2015B1237)
【分类号】：R563.9

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