结核感染T细胞斑点试验诊断老年患者肺结核的应用研究

发布时间：2018-07-14 13:10

【摘要】：目的通过对红细胞沉降率、结核抗体测定、痰结核菌涂片检查以及结核感染T细胞检测4种检查方法的比较,证明结核感染T细胞斑点试验诊断老年人肺结核更具有应用价值。方法 2012年1月-2013年12月收治的肺结核病老年患者中随机抽取100例作为试验组,再选择50例未患肺结核病老年患者作为对照组,分别对两组进行红细胞沉降率、结核抗体测定、痰结核菌涂片检查以及结核感染T细胞检测方法,对比记录4种方法检测效果。结果红细胞沉降率、结核抗体测定、痰结核菌涂片检查及结核感染T细胞检测的阳性率试验组患者分别为83.0%、59.0%、72.0%及98.0%,对照组分别为92.0%、8.0%、2.0%及0,结核感染T细胞检测阳性率高于优于红细胞沉降率检测、结核抗体测定和痰结核菌涂片检查,对比差异有统计学意义(P0.05);结核感染T细胞检测试验组阳性率较高,对照组无阳性检出,结核感染T细胞检测特异性达98.0%,敏感性100.0%。结论 4种检测方法中,使用结核感染T细胞斑点试验诊断老年人肺结核的检测效果显著,可明显提高诊断准确度,值得临床推广。
[Abstract]:Objective to compare the four detection methods of erythrocyte sedimentation rate, tuberculosis antibody test, sputum tuberculosis smear test and tuberculosis infection T cell detection method, and to prove that TB infected T cell spot test is more valuable in the diagnosis of senile pulmonary tuberculosis. Methods from January 2012 to December 2013, 100 elderly patients with pulmonary tuberculosis were randomly selected as experimental group, and 50 elderly patients without pulmonary tuberculosis were selected as control group. The erythrocyte sedimentation rate and tuberculosis antibody were measured respectively in the two groups. The methods of smear examination and T cell detection of tuberculosis infection were compared and recorded. Results erythrocyte sedimentation rate and tuberculosis antibody were measured. The positive rate of TB smear examination and TB infection T cell detection in the test group was 83.0% and 98.0%, respectively, and that in the control group was 92.0% and 2.0%, respectively. The positive rate of TB infection T cell was higher than that of erythrocyte sedimentation. Tuberculosis antibody test and sputum smear examination, the difference was statistically significant (P0.05). The positive rate of TB infection T cell test group was higher, the control group had no positive detection, the specificity of TB infection T cell detection was 98.0 and the sensitivity was 100.0. Conclusion among the four detection methods, the T cell spot test for tuberculosis infection is effective in the diagnosis of senile pulmonary tuberculosis, which can improve the diagnostic accuracy and is worth popularizing.
【作者单位】：山东省胸科医院传染科;乐陵市中医院护理部;
【基金】：山东省医药卫生科技基金资助项目(2013WS0147)
【分类号】：R521

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