阿奇霉素联合头孢噻肟钠对肺部感染患者炎性状态的控制效果观察

发布时间：2018-07-16 20:40

【摘要】：目的探讨阿奇霉素与头孢噻肟钠在肺部感染患者炎性状态控制中的临床应用价值。方法选取医院2014年6月-2015年6月确诊的98例肺部感染患者作为临床研究对象,根据药物治疗方案的不同将其分为观察组48例和对照组50例;对照组患者采用头孢噻肟钠治疗,观察组患者采用阿奇霉素联合头孢噻肟钠治疗,对两组患者的炎性状态控制情况进行比较分析。结果与对照组相比,观察组治疗后痊愈率58.33%及总有效率95.83%均明显提升,差异有统计学意义(P0.05);观察组经药物治疗后咳嗽、咳痰消失时间(3.98±1.21)d,气喘、气急消失时间(4.36±1.30)d,发热消失时间(3.32±1.15)d,肺部Up音消失时间(6.04±1.62)d均明显缩短,差异有统计学意义(P0.05);观察组经药物治疗后TNF-α(35.19±5.20)ng/L,IL-6(42.24±5.46)ng/L,CRP(37.37±5.29)mg/L等血清炎症因子水平均明显降低,差异有统计学意义(P0.05)。结论阿奇霉素联合头孢噻肟钠能够有效调节肺部感染患者的炎症因子水平,积极改善患者的临床症状和体征,全面提高患者的临床治疗效果。
[Abstract]:Objective to investigate the clinical value of azithromycin and cefotaxime sodium in the control of inflammatory state in patients with pulmonary infection. Methods 98 patients with pulmonary infection diagnosed in hospital from June 2014 to June 2015 were selected as clinical study subjects, and divided into observation group (n = 48) and control group (n = 50) according to the different drug treatment schemes, the control group was treated with cefotaxime sodium, and the patients in the control group were treated with cefotaxime sodium. Patients in the observation group were treated with azithromycin and cefotaxime sodium. Results compared with the control group, the cure rate and the total effective rate of the observation group were 58.33% and 95.83%, respectively, the difference was statistically significant (P0.05), the cough, expectoration and phlegm disappearance time of the observation group were (3.98 卤1.21) days. The time of sudden disappearance of qi was (4.36 卤1.30) days, the time of disappearance of fever was (3.32 卤1.15) days, the time of disappearance of pulmonary up was (6.04 卤1.62) days, the difference was statistically significant (P0.05), the levels of serum inflammatory factors such as TNF- 伪 (35.19 卤5.20) ng / L IL-6 (42.24 卤5.46) ng / L and CRP (37.37 卤5.29) mg / L in the observation group were significantly lower than those in the control group (P 0.05).
【作者单位】：濮阳市人民医院药剂科;
【基金】：河南省医学科技攻关项目(201409233)
【分类号】：R563.1

【相似文献】