耐多药肺结核流行现状分析

发布时间：2018-07-17 16:04

【摘要】：目的了解重庆地区耐多药肺结核流行现状,为进一步调整筛查策略及有效预防控制疫情扩散提供参考依据。方法调查收集2010年3月-2012年2月定点医院收治来自渝东北7个区县的耐多药肺结核病例资料,分析其发病情况和流行特征;采用SPSS19.0软件进行统计分析。结果 2010年3月-2012年2月共调查涂片阳性耐多药肺结核可疑者554例,检出耐多药肺结核患者37例,其中2例诊断为广泛耐药肺结核,涂阳肺结核患者耐多药率为6.68%,耐多药患者主要来自万州区,城乡差异无统计学意义,患者平均年龄(43.57±2.65)岁,男女性别比为2.36∶1,耐多药患者病死率21.62%;6类高危人群的MDR-TB检出率为24.51%;肺结核涂阳患者中初治耐多药率为3.04%,复治耐多药率为24.47%;7类不同涂阳患者类型中耐多药率最高的为复治失败患者,达66.67%。结论重庆地区耐多药肺结核发病水平与全国相当,有年轻化趋势,病情较重、病死率较高,复治失败患者是耐多药结核的高危人群;当前筛查策略趋于合理,仍需完善。
[Abstract]:Objective to investigate the prevalence of MDR-TB in Chongqing and to provide reference for further adjustment of screening strategy and effective prevention and control of epidemic spread. Methods from March 2010 to February 2012, the data of multi-drug resistant pulmonary tuberculosis (MDR-TB) cases from 7 counties in Northeast Chongqing were collected, and the incidence and epidemic characteristics of MDR-TB were analyzed by SPSS 19.0 software. Results from March 2010 to February 2012, a total of 554 smear-positive patients with MDR-TB were investigated and 37 cases of MDR-TB were detected, of which 2 cases were diagnosed as extensively drug-resistant pulmonary tuberculosis (MDR-TB). The multidrug resistance rate of smear positive pulmonary tuberculosis patients was 6.68. The patients with multidrug resistance mainly came from Wanzhou district. There was no significant difference between urban and rural areas. The average age of the patients was (43.57 卤2.65) years old. The ratio of male to female was 2.36: 1, the mortality rate of multidrug resistant patients was 21.622%, the MDR-TB rate was 24.51.The MDR-TB rate was 3.04 in patients with pulmonary tuberculosis smear positive, and the highest in different types of smear positive patients with pulmonary tuberculosis. For patients who have failed to return to treatment, Up to 66.67. Conclusion the incidence level of MDR-TB in Chongqing is similar to that of the whole country, with the tendency of young age, serious disease, high mortality rate and high risk group for MDR-TB, and the current screening strategy tends to be reasonable and still needs to be improved.
【作者单位】：重庆三峡中心医院感染管理科;
【基金】：国家科技重大专项基金项目(2008ZX10003-007)
【分类号】：R521

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