慢性阻塞性肺疾病患者FENO变化的临床意义及其与FEV1，FEV1%相关性研究

发布时间：2018-07-21 17:34

【摘要】：目的(1)分析慢性阻塞性肺疾病患者急性加重期(acute exacrbations of chronic obstructive pulmonary diseases,AECOPD)、稳定期及健康对照者的呼出气一氧化氮(fractional exhaled nitrie oxide,FENO)值;比较COPD患者急性加重期及稳定期的FENO探讨FENO在评估住院AECOPD患者气道炎症中的作用。(2)分析COPD患者急性加重期与稳定期FENO值与疗效的关系,探讨FENO值测定对住院COPD患者急性加重期治疗效果的评估意义。方法(1)以81例COPD急性加重期到稳定期患者为研究组,78例健康者为对照组,运用呼出气一氧化氮测定仪器NIOXMINO测定FENO值;同时使用肺功能仪肺功能计量器(美国麦加菲肺功能测试系统ELITE DL)测定其第一秒用力呼气容积(forced expiratory volume in one second,FEV1)、第一秒用力呼气容积占预计值的百分比(forced expiratory volume in one second/predicated value,FEV1%)。(2)COPD急性加重期患者进行综合治疗后,测定其稳定期FENO值及FEV1、FEV1%。结果(1)COPD患者急性加重期组FENO水平高于稳定期组;(2)COPD稳定期组FENO水平高于对照组;(3)COPD急性加重期组FENO水平高于稳定期组和对照组(P0.05);(4)相关关系研究发现:COPD急性加重期组患者FENO水平与FEV1、FEV1%均无相关性(P0.05);COPD稳定期组患者FENO水平与FEV1、FEV1%均无相关性(P0.05);急性加重期到稳定期FENO改善值与急性加重期到稳定期FEV1改善值之间存在正相关关系(P0.05),与急性加重期到稳定期FEV1%改善值之间亦存在正相关关系(P0.05)。结论(1)呼出气一氧化氮测定方法简单易行,具有无创、可重复且质控严格的优点。COPD急性加重期患者FENO值高于对照组,COPD稳定期患者FENO值下降;提示FENO可以反应COPD急性加重期患者气道炎症。(2)COPD急性加重期患者及COPD稳定期患者其FENO值下降程度与治疗后肺功能的改善存在相关性。
[Abstract]:Objective (1) to analyze the value of exhaled nitric oxide (fractional exhaled nitrie) in patients with acute exacerbation of chronic obstructive pulmonary disease (acute exacrbations of chronic obstructive pulmonary), stable stage and healthy controls. To investigate the role of FENO in evaluating airway inflammation in hospitalized AECOPD patients. (2) to analyze the relationship between FENO and efficacy in acute exacerbation and stable COPD patients. Objective: to evaluate the effect of FENO determination in acute exacerbation of COPD patients. Methods (1) Eighty-one COPD patients from acute exacerbation stage to stable stage were used as study group and 78 healthy subjects as control group. The FENO value was measured by the exhalation nitric oxide (NIOXMINO) instrument. Lung function Meter (American McGarfield Pulmonary function Measurement system ELITE DL) was used to measure the forced expiratory volume (forced expiratory volume in one second FEV1) and the percentage of forced expiratory volume in the first second (forced expiratory volume in one second/predicated) to the predicted value. Value of FEV1%). (2) after comprehensive treatment in patients with acute exacerbation of). (, The FENO value and FEV _ 1 of FEV _ 1 were measured. Results (1) the level of FENO in the acute exacerbation group was higher than that in the stable phase group, (2) the FENO level in the stable phase group was higher than that in the control group, and (3) the FENO level in the acute exacerbation group was higher than that in the stable phase group and the control group (P0.05). There was no correlation between FENO level and FEV1% (P0.05), there was no correlation between FENO level and FEV1% in COPD stable group (P0.05), and there was a positive correlation between FENO improvement value and FEV1 improvement value in acute exacerbation period to stable phase (P0.05), and there was a positive correlation between FENO level and FEV1 improvement value during acute exacerbation period to stable phase (P0.05), and there was a positive correlation between FENO level and FEV1 improvement value during acute exacerbation period to stable phase (P0.05). There was also a positive correlation between FEV 1% improvement value and stable FEV improvement value (P0.05). Conclusion (1) the determination method of exhalation nitric oxide is simple, noninvasive, repeatable and strict in quality control. The FENO value of COPD patients in acute exacerbation stage is higher than that in the control group. The results suggest that FENO can reflect airway inflammation in patients with acute exacerbation of COPD. (2) the decrease of FENO in patients with acute exacerbation of COPD and stable COPD is related to the improvement of pulmonary function after treatment.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R563.9
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本文编号：2136270