清除幽门螺杆菌对老年COPD患者肺功能检测小气道参数的影响

发布时间：2018-07-22 15:38

【摘要】：目的探讨清除幽门螺杆菌(Hp)对老年慢性阻塞性肺病(COPD)患者肺功能检测小气道参数的影响。方法稳定期COPD患者行~(13)C-尿素呼气试验(~(13)C-UBT)检测,选取40例~(13)C-UBT阳性患者,即Hp感染的COPD病例为研究对象。再次进行肺功能检查,测定小气道参数[最大呼气中期流量(MMEF)、呼出用力肺活量50%时流速(FEF50%)、FEF75%]。所有患者均进行Hp的根除治疗2 w。1个月后复查~(13)C-UBT,剔除阳性病例,重新测定小气道参数。比较治疗前后患者小气道参数的变化情况。结果 40例患者Hp均根除成功,根除率为100.00%;根除Hp后MMEF、FEF50、FEF25~75、FEF75分别为(2.68±0.71)ml、(72.52±22.52)%、(70.24±21.02)%、(67.74±20.08)%,均明显高于根除Hp前(1.85±0.62)ml、(22.52±15.23)%、(22.31±14.98)%、(18.56±11.25)%(P0.05)。结论清除Hp可显著提高老年COPD患者小气道参数,改善患者肺功能,促进患者身体恢复。
[Abstract]:Objective to investigate the effect of Helicobacter pylori (HP) clearance on small airway parameters in elderly patients with chronic obstructive pulmonary disease (COPD). Methods ~ (13) C-urea breath test (~ (13) C-UBT) was performed in stable COPD patients. Pulmonary function was examined again and the parameters of small airway were measured [maximum mid-expiratory flow (MMEF), forced vital capacity exhalation (FEF50%) and FEF75%]. All the patients were treated with HP eradication therapy for 2 w.1 months after reexamination of ~ (13) C-UBT.The positive cases were eliminated and the parameters of small airway were measured again. The changes of small airway parameters before and after treatment were compared. Results all the 40 patients were successfully eradicated, the eradication rate was 100.000.After HP eradication, MMEFFFEF50 FEF2575 FEF75 was (2.68 卤0.71) ml, (72.52 卤22.52), (70.24 卤21.02), (67.74 卤20.08), significantly higher than that before HP eradication (1.85 卤0.62) ml, (22.52 卤15.23), (22.31 卤14.98), (18.56 卤11.25)% (P0.05). Conclusion removal of HP can significantly improve the small airway parameters, improve the pulmonary function and promote the recovery of patients with COPD.
【作者单位】：包头医学院第一附属医院;
【基金】：内蒙古科技大学包头医学院第一附属医院科学研究基金资助(No.BYJJ-QM2016113)
【分类号】：R563.9

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