支气管扩张患者中致病菌感染与肺功能相关性分析

发布时间：2018-07-25 10:29

【摘要】：目的探讨支气管扩张(BD)不同病情严重程度与非病毒性病原体感染的相关性,为BD病情发展预判提供重要的临床数据。方法分析224例BD患者细菌感染类型、通气功能,评估不同细菌感染与BD病情严重程度的相关性。结果 224例患者中气道分泌物的致病菌培养阳性103例(45.98%),阳性标本中共分离出优势病原菌114株。其中弥漫型检出率明显高于局部型(P0.01);弥漫型病变以革兰阴性菌(G-)为主,局部型病变以革兰阳性菌(G+)为主,差异有统计学意义(P0.01)。感染的BD患者中限制性类型占比最高,明显高于其他类型(P0.05);弥漫型和局部型BD患者的通气功能类型均与致病菌感染的类型相关(P0.05)。弥漫型BD患者的通气功能损伤程度和弥散功能均与致病菌感染的类型相关(P0.05)。结论 BD患者感染细菌后其肺功能与致病菌感染和感染类型存在关联性,有利于临床BD患者细菌感染后的病情严重程度的预判,为临床BD细菌感染标准化诊疗流程的建立补充和完善可靠的临床数据。
[Abstract]:Objective to investigate the relationship between the severity of bronchiectasis (BD) and non-viral pathogens infection, and to provide important clinical data for the prediction of BD. Methods the types of bacterial infection and ventilation function in 224 patients with BD were analyzed and the correlation between bacterial infection and severity of BD was evaluated. Results of 224 cases, 103 (45.98%) were positive for pathogenic bacteria in airway secretion, 114 strains of dominant pathogens were isolated from positive samples. The detection rate of diffuse type was significantly higher than that of local type (P0.01), the most of diffuse lesions were Gram-negative bacteria (G-), and the local lesions were Gram-positive bacteria (G), the difference was statistically significant (P0.01). The proportion of restrictive type was the highest in BD patients with infection, which was significantly higher than that of other types (P0.05); the ventilatory function types of diffuse type and local type BD patients were correlated with the type of pathogenic bacteria infection (P0.05). The degree of ventilatory function injury and diffusive function in patients with diffuse BD were correlated with the type of pathogenic bacteria infection (P0.05). Conclusion the pulmonary function of BD patients after bacterial infection is related to the infection and type of pathogenic bacteria, which is helpful to predict the severity of bacterial infection in patients with BD. To supplement and perfect the reliable clinical data for the standardized diagnosis and treatment of BD bacterial infection.
【作者单位】：四川省广元市第一人民医院呼吸科;四川省广元市第一人民医院检验科;
【分类号】：R446.5;R562.22

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