医院获得性肺炎患者炎症因子的相关性研究

发布时间：2018-08-08 15:16

【摘要】：目的观察白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子α(TNF-α)、降钙素原(PCT)、可溶性髓系细胞触发受体-1(sTREM-1)在医院获得性肺炎患者中的表达及意义,为尽早诊断及治疗医院获得性肺炎提供依据。方法选择2013年7月-2016年6月医院获得性肺炎患者196例作为HAP组,同期门诊体检健康志愿者195名为健康组,28d内存活的患者纳入HAP存活组,28d内死亡的患者纳入HAP死亡组,分别在诊断入组第1、4、7天、出院或死亡当日检测IL-6、IL-10、TNF-α、PCT、sTREM-1在HAP患者血清内的水平。结果 HAP组的sTREM-1、IL-6、IL-10、TNF-α、PCT水平均明显高于健康组,且HAP死亡组上述指标水平高于生存组;在治疗过程中,存活组HAP患者sTREM-1、IL-6、IL-10水平均低于死亡组,差异有统计学意义(P0.05);存活组HAP患者sTREM-1、IL-6、IL-10水平随治疗时间的增加而逐渐减低,两两比较差异有统计学意义(P0.05);存活组HAP患者TNF-α、PCT水平在治疗第1、4、7天及出院或死亡当日均低于死亡组,差异有统计学意义;存活组HAP患者TNF-α、PCT水平随治疗时间的增加而逐渐减低,两两比较有统计学意义。结论 sTREM-1、IL-6、IL-10、TNF-α、PCT水平在HAP患者的表达明显高于健康人群,其水平越高,炎症反应越严重,治疗预后越差。
[Abstract]:Objective to investigate the expression and significance of interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor- 伪 (TNF- 伪), calcitonin proto-( PCT), soluble myeloid cell trigger receptor (sTREM-1) in patients with nosocomial pneumonia. To provide evidence for early diagnosis and treatment of nosocomial pneumonia. Methods 196 patients with nosocomial pneumonia from July 2013 to June 2016 were selected as HAP group. 195 healthy volunteers in outpatient clinic were included in HAP survival group within 28 days and those who died within 28 days were included in HAP death group. The serum levels of IL-6, IL-10, TNF- 伪 and PCTN TREM-1 in patients with HAP were detected on the 7th day of the first day of diagnosis and on the day of discharge or death. Results the levels of sTREM-1IL-10TNF- 伪 -PCT in the HAP group were significantly higher than those in the healthy control group, and the above indexes in the HAP death group were higher than those in the survival group, and in the course of treatment, the level of sTREM-1 IL-6IL-10 in the HAP patients in the survival group was lower than that in the dead group. The level of IL-10 of sTREM-1m-1 IL-6 was decreased with the increase of treatment time in survival group (P0.05), and the level of TNF- 伪 -PCT in HAP group was lower than that in death group on the 1st day of treatment and on the day of discharge or death (P0.05), and the level of IL-10 in survival group was significantly lower than that in the control group (P0.05), while in the survival group, the level of TNF- 伪 -PCT was significantly lower than that in the control group (P0.05). The level of TNF- 伪 -PCT in survival group decreased gradually with the increase of treatment time, and there was significant difference between two groups. Conclusion the expression of TNF- 伪 PCT in patients with HAP is significantly higher than that in healthy subjects. The higher the level, the more serious the inflammatory reaction and the worse the prognosis of treatment.
【作者单位】：淄博市第一医院综合内科;
【分类号】：R563.1

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