PCT与CRP变化对高血压脑出血合并老年肺部感染患者的预后影响

发布时间：2018-08-12 17:36

【摘要】：目的探讨血清降钙素原(PCT)、血清C-反应蛋白(CRP)水平变化在高血压脑出血术后合并肺部感染老年患者抗感染中的价值及对预后影响,为高血压脑出血合并肺部感染患者治疗效果及预后提供依据。方法收集医院2014年1月-2015年1月收治高血压脑出血微创术后合并肺部感染患者68例设为观察组,另选择同期住院微创术后未合并肺部感染患者68例定为对照组;两组术后均给予3d预防性抗感染治疗,观察两组患者术后不同时间炎性指标(PCT、CRP及WBC)变化,详细记录两组患者术后30d内死亡情况。结果两组术后预防性抗感染3dCRP、PCT高于术后当天(P0.05),术后及术后预防性抗感染3d WBC对比,差异无统计学意义;观察组于术后6d确诊合并肺部感染,两组术后5dCRP、PCT及WBC对比,差异无统计学意义,术后10、15d CRP、PCT及WBC均高于术后5d及对照组(P0.05);观察组术后30d内死亡8例,病死率为11.76%,死亡患者CRP、PCT高于生存患者(P0.05)。结论高血压脑出血术后合并肺部感染老年患者抗感染治疗过程中,检测PCT、CRP水平变化可指导抗感染治疗,且可预测治疗结局。
[Abstract]:Objective to investigate the value of serum C- reactive protein (CRP) level in serum procalcitonin (PCT),) in elderly patients with pulmonary infection after hypertensive intracerebral hemorrhage (hypertensive intracerebral hemorrhage) and its effect on prognosis. To provide evidence for the treatment and prognosis of hypertensive intracerebral hemorrhage complicated with pulmonary infection. Methods Sixty-eight patients with pulmonary infection after minimally invasive operation for hypertensive intracerebral hemorrhage in our hospital from January 2014 to January 2015 were selected as observation group, and 68 patients without pulmonary infection after minimally invasive operation in the same period were selected as control group. The patients in both groups were treated with prophylactic anti-infective therapy for 3 days. The changes of inflammatory markers (PCTV-CRP and WBC) at different time after operation were observed, and the death rate within 30 days after operation was recorded in detail. Results the WBC of the two groups on the 3rd day after operation was higher than that on the day of operation (P0.05). There was no significant difference in WBC between the two groups on the 3rd day after operation, and there was no significant difference between the two groups on the 6th day after operation, and the comparison between the two groups on the 5th day after operation. There was no significant difference between the two groups (P < 0.05). The CRPP-PCT and WBC were significantly higher in the observation group than in the control group on the 10th and 15th day after operation (P0.05), while in the observation group, 8 patients died within 30 days after operation, the mortality rate was 11.76%, and the death group was higher than that in the survival group (P0.05). Conclusion in the course of anti-infection treatment in elderly patients with hypertensive intracerebral hemorrhage complicated with pulmonary infection, the change of PCT-CRP level can guide the anti-infection therapy and predict the outcome of the treatment.
【作者单位】：郑州大学附属洛阳中心医院护理部;郑州颐和医院护理部;郑州大学附属洛阳中心医院神经内科;
【基金】：河南省卫生厅基金资助项目(20139840183L)
【分类号】：R563.1;R651.12

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