动态监测降钙素原对判断细菌性医院获得性肺炎患者预后的意义

发布时间：2018-08-18 18:50

【摘要】：目的:探讨降钙素原(PCT)水平及治疗后下降趋势对细菌性医院获得性肺炎(HAP)患者生存的影响。方法:回顾性分析2012年01月至2013年01月收治的HAP患者113例(死亡组64例,存活组49例)和92例正常对照组患者的PCT值与住院天数、生存率之间的关系。结果:死亡组和存活组患者的初始PCT值高于正常对照组,而死亡组比存活组的PCT值升高更明显,差异有统计学意义(P=0.0002)。初始PCT值为0.78μg/L时预测HAP病死价值的灵敏度和特异度分别是0.66和0.7。死亡组患者的PCT值与住院天数存在显著的负相关关系。治疗后PCT下降50%组患者生存率显著高于PCT下降50%组患者。结论:动态监测降钙素原对判断细菌性HAP患者预后有一定的意义。
[Abstract]:Objective: to investigate the effect of procalcitonin (PCT) level and decreasing trend after treatment on the survival of (HAP) patients with bacterial hospital acquired pneumonia. Methods: from January 2012 to January 2013, 113 patients with HAP (64 patients in the death group and 49 patients in the survival group) and 92 normal controls were analyzed retrospectively. The relationship between the PCT value and the days of hospitalization and the survival rate was analyzed. Results: the initial PCT value of the patients in the death group and the survival group was higher than that in the normal control group, while the PCT value in the dead group was significantly higher than that in the surviving group (P0. 0002). When the initial PCT value was 0.78 渭 g / L, the sensitivity and specificity of predicting the death value of HAP were 0.66 and 0.7, respectively. There was a significant negative correlation between PCT and hospitalization days in the death group. The survival rate of patients with 50% decrease of PCT after treatment was significantly higher than that of patients with 50% decrease of PCT. Conclusion: dynamic monitoring of procalcitonin has a certain significance in judging the prognosis of patients with bacterial HAP.
【作者单位】：南方医科大学南方医院呼吸与危重症医学科;珠海市人民医院;
【基金】：广东省教育部产学研结合项目(编号:2012B091100153) 广东省科技计划项目(编号:2011B031800245)
【分类号】：R563.1

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