长期联合应用噻托溴铵干粉与沙美特罗替卡松粉剂对中老年慢性阻塞性肺疾病稳定期患者的疗效与预后观察

发布时间：2018-08-19 16:37

【摘要】：目的观察噻托溴铵与沙美特罗替卡松干粉剂联合应用对重度、极重度稳定期中老年慢性阻塞性肺疾病(COPD)患者的疗效与预后影响。方法选取80例稳定期中老年重度极重度COPD患者,采用完全随机方法分成两组,一组联合应用噻托溴铵及沙美特罗替卡松干粉剂,一组单用噻托溴铵,共治疗12个月。分别于用药后1、3、6、12个月测定患者①肺功能,②6 min步行试验,③圣乔治问卷,④记录急性加重次数、加重出现时间。结果两组患者治疗后不同时期肺功能指标、6 min步行试验及圣乔治问卷评分较治疗前均有明显改善(P0.05)。与单药组比较,联合组各项指标改善更明显(P0.05)。结论噻托溴铵与沙美特罗替卡松干粉剂联合应用对于重度、极重度中老年COPD患者的肺功能、运动耐量及生活质量的影响明显优于噻托溴铵治疗,且药物联合应用,不良反应未见明显增加。
[Abstract]:Objective to observe the effect and prognosis of tiotropium bromide combined with salmeterolticasone dry powder in the treatment of severe and very severe stable chronic obstructive pulmonary disease (COPD) patients. Methods 80 elderly patients with severe and severe COPD were randomly divided into two groups. One group was treated with tiotropium bromide and salmeterticasone dry powder, the other group was treated with tiotropium bromide alone for 12 months. The acute aggravation times and the onset time of acute exacerbation were recorded in 1 lung function 26 min walking test 3 St George's questionnaire and 12 months after treatment. Results the lung function index of 6 min walking test and St George's questionnaire score were significantly improved in two groups after treatment (P0.05). Compared with the single drug group, the combined group improved more obviously (P0.05). Conclusion the effects of tiotropium bromide combined with salmeterolticasone dry powder on lung function, exercise tolerance and quality of life of patients with severe and very severe COPD were significantly better than those of tiotropium bromide. There was no significant increase in adverse reactions.
【作者单位】：河北医科大学附属沧州市中心医院呼吸一科;
【分类号】：R563.9

【参考文献】