N末端B型利钠肽原和尿酸水平在肺动脉血栓栓塞症和慢性心力衰竭的比较

发布时间：2018-08-24 21:33

【摘要】：目的:比较N末端B型利钠肽原(NT-proBNP)和尿酸在肺动脉血栓栓塞症(PTE)和慢性心力衰竭(CHF)中的水平差异。方法:采用前瞻性研究方法,收集2010-06至2015-05因急性呼吸困难就诊于我院的患者288例,根据诊断标准将患者分为PTE组107例和CHF组181例。对所有患者均检测血NT-proBNP和尿酸。运用SPSS 17.0软件进行统计学分析,组间比较采用独立样本t检验或者方差分析。结果:CHF组和PTE组患者以男性多见,在PTE组占59.8%(64/107),在CHF组占56.9%(103/181)。血NT-proBNP和尿酸水平PTE组均低于CHF组[NT-proBNP水平:(2421.7±1678.1)pg/ml vs(6964.3±3873.1)pg/ml,P0.01和尿酸水平:(340.6±121.3)μmol/L vs(492.1±166.2)μmol/L,P0.01]。结论:PTE组血NT-proBNP和尿酸的水平均显著低于CHF组。在结合临床背景下,血NT-proBNP和尿酸水平可能协助识别以急性呼吸困难为主要临床表现的PTE和CHF。
[Abstract]:Aim: to compare the levels of N-terminal B-type natriuretic peptide (NT-proBNP) and uric acid in pulmonary thromboembolism (PTE) and chronic heart failure (CHF) (CHF). Methods: a prospective study was used to collect 288 patients with acute dyspnea from 2010-06 to 2015-05. According to the diagnostic criteria, the patients were divided into PTE group (107 cases) and CHF group (181 cases). Serum NT-proBNP and uric acid were detected in all patients. SPSS 17.0 software was used for statistical analysis, and independent sample t-test or ANOVA was used for the comparison between groups. Results male patients were more common in the PTE group than in the control group, 59.8% (64 / 107) in the PTE group and 56.9% (103 / 181) in the CHF group. Serum NT-proBNP and uric acid levels in PTE group were lower than those in CHF group [NT-proBNP level: (2421.7 卤1678.1) pg/ml vs (6964.3 卤3873.1) pg/ml,P0.01 and uric acid level: (340.6 卤121.3) 渭 mol/L vs (492.1 卤166.2) 渭 mol/L,P0.01]. Conclusion the levels of serum NT-proBNP and uric acid in the group of w Pte were significantly lower than those in the group of CHF. In combination with clinical background, serum NT-proBNP and uric acid levels may assist in identifying PTE and CHF. with acute dyspnea as the main clinical manifestation.
【作者单位】：山东大学附属省立医院;莱芜市妇幼保健院;
【基金】：国家“十二五”科技支撑课题(2011BAI11B17) 山东省自然科学基金课题(ZR2014HM083)
【分类号】：R541.4;R563.5

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